Description:

FordetectionoftripeptidylpeptidaseII(TPPII).TPPIIplaysacriticalroleincleavingproteasomal-producedpeptidesintotripeptidesthatcanbefurtherdegradedbyotherpeptidases.Inadditiontoaphysiologicalrôlethatisconcernedwithgeneralproteinturnover,therearemorespecificrôlesforTPPII,suchasitsrôleinmajorhistocompatibilitycomplex(MHC)classIantigenprocessing.

ProductSpecification:

AlternativeName:	TPPII
Host:	Rabbit
Immunogen:	ErythrocyteextractedfulllengthhumanTPPII(tripeptidylpeptidaseII).
UniProtID:	P29144
Speciesreactivity:	Human
Applications:	WB
RecommendedDilutions/Conditions:	WesternBlot(1:500-1:1,000) Suggesteddilutions/conditionsmaynotbeavailableforallapplications. Optimalconditionsmustbedeterminedindividuallyforeachapplication.
PurityDetail:	Partiallypurifiedbysaltprecipitation.
Formulation:	Liquid.InPBScontaining0.01%sodiumazide.
Use/StABIlity:	Stableforatleast1yearafterreceiptwhenstoredat-20°C.Theuseofhighquality‘antiserum-grade’plasticorglassvialsisrecommended.Storedilutedantibodyat2-4°C(donotfreeze)andusewithin1month.
Handling:	Avoidfreeze/thawcycles.Afteropening,preparealiquotsandstoreat-20°C.
Shipping:	ShippedonBlueIce
ShortTermStorage:	-20°C
LongTermStorage:	-20°C
ScientificBackground:	TPPIIplaysacriticalroleincleavingproteasomeal-producedpeptidesintotripeptidesthatcanbefurtherdegradedbydipeptidylpeptidaseII(DPPII)andaminopeptidases.Inadditiontoaphysiologicalrôlethatisconcernedwithgeneralproteinturnover,therearemorespecificrôlesforTPPII,suchasitsrôleinmajorhistocompatibilitycomplex(MHC)classIantigenprocessinginthecytosolicsubtilisin.Inaddtiontoexo-peptidaseactivity,TPPIIalsoexhibitsendo-proteolyticcleavageproperties.TPPIImayalsogenerateantigenicpeptidesforthetransporterassociatedwithantigenprocessing(TAP)andappearstobeanimportantintermediatebetweentheproteasomeandtherestofthepeptidasepoolinvolvedintrimmingoflargerfragmentstoantigenicpeptidesandmainlyfreeaminoacids.

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