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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
- Specification
- Product Description:
- Labeled FISH probes for identification of gene split using Fluoresecent In Situ Hybridization Technique. (Technology)
- Form:
- Liquid
- Quality Control Testing:
- Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
- Supplied Product:
- DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
- Storage Instruction:
- Store at 4°C in the dark.
- Note:
- Hybridization position of the probes on the chromosome:
- Probe 1:Size:Fluorophore:Location:
- ABL1Approximately 340kbTexas Red9q34.1
- Probe 2:Size:Fluorophore:Location:
- ABL1Approximately 650kbFITC9q34.1
- Origin:
- Human
- Source:
- Genomic DNA
- Notice:
- We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
- Regulation Status:
- For research use only (RUO)
- Datasheet:
Download
- Applications
- Fluorescent In Situ Hybridization (Cell)
- Protocol Download
- Application Image
- Fluorescent In Situ Hybridization (Cell)
- Gene Information
- Entrez GeneID:
- 25
- Gene Name:
- ABL1
- Gene Alias:
- ABL,JTK7,bcr/abl,c-ABL,p150,v-abl
- Gene Description:
- c-abl oncogene 1, receptor tyrosine kinase
- Omim ID:
- 189980
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response.Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene.The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia.The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq
- Other Designations:
- Abelson murine leukemia viral (v-abl) oncogene homolog 1,OTTHUMP00000022375,OTTHUMP00000022376,bcr/c-abl oncogene protein,proto-oncogene tyrosine-protein kinase ABL1,v-abl Abelson murine leukemia viral oncogene homolog 1
- Gene Pathway
- Axon guidance
- Cell cycle
- Chronic myeloid leukemia
- ErbB signaling pathway
- Neurotrophin signaling pathway
- Pathogenic Escherichia coli infection - EHEC
- Pathways in cancer
- Related Disease
- Adenocarcinoma
- Alzheimer Disease
- Alzheimer disease
- Breast cancer
- Breast Neoplasms
- Cardiovascular Diseases
- Chronic Disease
- Diabetes Complications
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- HIV Infections
- Leukemia, chronic myeloid
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Leukemia, Myeloid
- Leukemia, Myeloid, Chronic
- Metabolic Syndrome X
- Neoplasms
- Osteoporosis
- Ovarian cancer
