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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
- Specification
- Product Description:
- This antibody pair set comes with matched antibody pair to detect and quantify protein level of human ACTN4.
- Reactivity:
- Human
- Quality Control Testing:
- Standard curve using recombinant protein ( H00000081-P01 ) as an analyte.Sandwich ELISA detection sensitivity ranging from 3 ng/ml to 100 ng/ml.
- Supplied Product:
- Antibody pair set content: 1. Capture antibody: mouse monoclonal anti-ACTN4, IgG2b Kappa (100 ug) 2. Detection antibody: biotinylated mouse monoclonal anti-ACTN4, IgG1 Kappa (50 ug) *Reagents are sufficient for at least 3-5 x 96 well plates using recommended protocols.
- Storage Instruction:
- Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
- Interspecies Antigen Sequence:
- Mouse (98%); Rat (98%)
- Datasheet:
Download
- Applications
- ELISA Pair (Recombinant protein)
- Protocol Download
- Application Image
- ELISA Pair (Recombinant protein)
- Gene Information
- Entrez GeneID:
- 81
- Gene Name:
- ACTN4
- Gene Alias:
- ACTININ-4,DKFZp686K23158,FSGS,FSGS1
- Gene Description:
- actinin, alpha 4
- Omim ID:
- 603278, 604638
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins.Alpha actinin is an actin-binding protein with multiple roles in different cell types.In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane.In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes.Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq
- Other Designations:
- actinin alpha4 isoform
- Interactome
- Gene Pathway
- Adherens junction
- Arrhythmogenic right ventricular cardiomyopathy (ARVC)
- Focal adhesion
- Leukocyte transendothelial migration
- Regulation of actin cytoskeleton
- Systemic lupus erythematosus
- Tight junction
- Related Disease
- Alport syndrome
- Cardiovascular Diseases
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Diabetic Nephropathies
- Edema
- Genetic Predisposition to Disease
- Glomerulosclerosis, Focal Segmental
- Kidney Diseases
- Proteinuria
