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品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
- Specification
- Product Description:
- Labeled FISH probes for identification of gene split using Fluoresecent In Situ Hybridization Technique. (Technology)
- Form:
- Liquid
- Quality Control Testing:
- Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
- Supplied Product:
- DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
- Storage Instruction:
- Store at 4°C in the dark.
- Note:
- Hybridization position of the probes on the chromosome:
- Probe 1:Size:Fluorophore:Location:
- COL1A1Approximately 570kbTexas Red17q21.33
- Probe 2:Size:Fluorophore:Location:
- COL1A1Approximately 730kbFITC17q21.33
- Origin:
- Human
- Source:
- Genomic DNA
- Notice:
- We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
- Regulation Status:
- For research use only (RUO)
- Datasheet:
Download
- Applications
- Fluorescent In Situ Hybridization (Cell)
- Protocol Download
- Application Image
- Fluorescent In Situ Hybridization (Cell)
- Gene Information
- Entrez GeneID:
- 1277
- Gene Name:
- COL1A1
- Gene Alias:
- OI4
- Gene Description:
- collagen, type I, alpha 1
- Omim ID:
- 114000, 120150, 130000, 130060, 166200, 166210, 166220, 166710, 259420
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish
- Other Designations:
- alpha 1 type I collagen,collagen alpha 1 chain type I,collagen of skin, tendon and bone, alpha-1 chain,pro-alpha-1 collagen type 1,type I collagen alpha 1 chain
- Gene Pathway
- ECM-receptor interaction
- Focal adhesion
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Aortic Aneurysm, Abdominal
- beta-Thalassemia
- Body Weight
- Bone Diseases
- Bone Diseases, Metabolic
- Bone Neoplasms
- Cardiovascular Diseases
- Chorioamnionitis
- Chronic Disease
- Clubfoot
- Colles" Fracture
- Connective Tissue Diseases
- Coronary Artery Disease
- Crohn Disease
- Crohn"s disease
- Cystic Fibrosis
- Cystic fibrosis
