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公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
- Specification
- Product Description:
- Labeled FISH probes for identification of gene translocation using Fluoresecent In Situ Hybridization Technique. (Technology)
- Form:
- Liquid
- Quality Control Testing:
- Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
- Supplied Product:
- DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
- Storage Instruction:
- Store at 4°C in the dark.
- Note:
- Hybridization position of the probes on the chromosome.
- Probe 1:Size:Fluorophore:Location:
- EWSR1Approximately 590kb FITC22q12
- Probe 2:Size:Fluorophore:Location:
- ATF1Approximately 470kb TexRed12q13.12
- Origin:
- Human
- Source:
- Genomic DNA
- Notice:
- We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
- Regulation Status:
- For research use only (RUO)
- Datasheet:
Download
- Applications
- Fluorescent In Situ Hybridization (Cell)
- Protocol Download
- Application Image
- Fluorescent In Situ Hybridization (Cell)
- ATF1
- EWSR1
- Gene Information
- Entrez GeneID:
- 2130
- Gene Name:
- EWSR1
- Gene Alias:
- EWS
- Gene Description:
- Ewing sarcoma breakpoint region 1
- Omim ID:
- 133450
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq
- Other Designations:
- Ewings sarcoma EWS-Fli1 (type 1) oncogene,bK984G1.4 (Ewing sarcoma breakpoint region 1 protein)
- Gene Information
- Entrez GeneID:
- 466
- Gene Name:
- ATF1
- Gene Alias:
- EWS-ATF1,FUS/ATF-1,TREB36
- Gene Description:
- activating transcription factor 1
- Omim ID:
- 123803
- Gene Ontology:
- Hyperlink
- Other Designations:
- -
