- Product Description:
- Recombinant mouse monoclonal antibody raised against human ABCB1.
- Immunogen:
- Original antibody is raised against drug resistant K-562 cells.
- Specificity:
- This antibody recognizes a discontinuous extracellular epitope on human ABCB1.
- Purification:
- Protein A affinity purification
- Recommend Usage:
- Flow Cytometry (1 ug/mL)ImmunofluorescenceImmunoprecipitation (10 ug/mL)The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS, pH 7.2 (0.02% Proclin 300).
- Storage Instruction:
- Store at 4°C for up to 3 months. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
- Datasheet:
Download
- Protein Accession#:
- P08183
- Gene Alias:
- ABC20,CD243,CLCS,GP170,MDR1,MGC163296,P-GP,PGY1
- Gene Description:
- ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Gene Summary:
- The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq
- Other Designations:
- ATP-binding cassette, subfamily B, member 1,P glycoprotein 1,P-glycoprotein 1,colchicin sensitivity,doxorubicin resistance,multidrug resistance 1,multidrug resistance protein 1
- Acquired Immunodeficiency Syndrome
- Acute Disease
- Addison Disease
- Adenocarcinoma
- Adenoma
- Alcoholism
- Alzheimer Disease
- Alzheimer disease
- Amnesia
- Anemia
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Atherosclerosis
- Attention Deficit Disorder with Hyperactivity
- Bipolar Disorder
- Birth Weight
- Body Weight
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Ductal, Breast
- Carcinoma, Endometrioid
- Carcinoma, Hepatocellular
- Carcinoma, Lobular
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Renal Cell
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- Central Nervous System Diseases
- Central Nervous System Neoplasms
- Child Development Disorders, Pervasive
- Cholangitis, Sclerosing
- Chronic Disease
- Cleft Lip
- Cleft Palate
- Cognition Disorders
- Colitis, Ulcerative
- Colon cancer
- Colonic Neoplasms
- Colorectal Neoplasms
- Coronary Artery Disease
- Coronary Disease
- Coronary Restenosis
- Crohn Disease
- Crohn"s disease
- Cystadenocarcinoma, Serous
- Cystic Fibrosis
- Cystic fibrosis
- Delayed Graft Function
- Depressive Disorder
- Depressive Disorder, Major
- Diabetes Complications
- Diabetes Mellitus
- Diabetes Mellitus, Type 2
- Diarrhea
- Disease Progression
- Drug Toxicity
- Drug-Induced Liver Injury
- Duodenal Ulcer
- Dyskinesia, Drug-Induced
- Dyslipidemias
- Edema
- Encephalomyelitis, Autoimmune, Experimental
- Endometrial Neoplasms
- Epilepsies, Partial
- Epilepsy
- Epilepsy
- Epilepsy, Generalized
- Epilepsy, Temporal Lobe
- Esophageal Neoplasms
- Familial Mediterranean Fever
- Familial Mediterranean fever
- Femur Head Necrosis
- Gastritis
- Gastroesophageal Reflux
- Gastrointestinal Diseases
- Gastrointestinal Stromal Tumors
- Gastroparesis
- Genetic Predisposition to Disease
- Gilbert Disease
- Gingival Hyperplasia
- Gingival Overgrowth
- Glioblastoma
- Glioma
- Graft vs Host Disease
- Graves Disease
- Hashimoto Disease
- Head and Neck Neoplasms
- Helicobacter Infections
- Hematologic Diseases
- Hemophilia A
- Hemorrhage
- Hepatitis B
- Heroin Dependence
- HIV Infections
- HIV Seropositivity
- Hyperbilirubinemia
- Hypercholesterolemia
- Hyperlipidemias
- Hyperlipoproteinemia Type II
- Hypertension
- Hyperthyroidism
- Hyponatremia
- Hypotension, Orthostatic
- Hypothyroidism
- Infection
- Infertility, Male
- Inflammation
- Inflammatory Bowel Diseases
- Kidney Diseases
- Kidney Failure
- Kidney Failure, Chronic
- Kidney Neoplasms
- Leukemia
- Leukemia, B-Cell, Chronic
- Leukemia, chronic myeloid
- Leukemia, Erythroblastic, Acute
- Leukemia, Lymphocytic
- Leukemia, Lymphocytic, Acute
- Leukemia, Lymphocytic, Acute, L1
- Leukemia, Lymphocytic, Chronic
- Leukemia, Megakaryoblastic, Acute
- Leukemia, Monocytic, Acute
- Leukemia, Myelocytic, Acute
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Leukemia, Myeloid
- Leukemia, Myeloid, Acute
- Leukemia, Myeloid, Chronic
- Leukemia, Myelomonocytic, Acute
- Leukemia, Promyelocytic, Acute
- Leukopenia
- Liver Cirrhosis, Biliary
- Liver Diseases
- Liver Neoplasms
- Lung Neoplasms
- Lupus Erythematosus, Systemic
- Lupus Nephritis
- Lymphatic Metastasis
- Lymphoma, Non-Hodgkin
- Lymphoma, T-Cell, Cutaneous
- Lymphoma, T-Cell, Peripheral
- Lymphoproliferative Disorders
- Malaria
- Marijuana Abuse
- Mental Disorders
- Mental Status Schedule
- Metabolic Syndrome X
- Microsatellite Instability
- Miosis
- Mood Disorders
- Movement Disorders
- Multiple Myeloma
- Multiple Sclerosis
- Myasthenia Gravis
- Myocardial Infarction
- Nasopharyngeal Neoplasms
- Nausea
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Neoplasm Recurrence, Local
- Neoplasm, Residual
- Neoplasms
- Neovascularization, Pathologic
- Nephrotic Syndrome
- Nervous System Diseases
- Neuropsychological Tests
- Neurotoxicity Syndromes
- Neutropenia
- Obesity
- Obesity
- Opioid-Related Disorders
- Opportunistic Infections
- Osteonecrosis
- Osteoporosis
- Ovarian cancer
- Ovarian Neoplasms
- Pain
- Pain Threshold
- Pain, Postoperative
- Pancreatitis, Alcoholic
- Parkinson Disease
- Parkinson disease
- Peptic Ulcer
- Peripheral Nervous System Diseases
- Postoperative Complications
- Postoperative Nausea and Vomiting
- Prostate cancer
- Prostatic Neoplasms
- Pruritus
- Psychiatric Status Rating Scales
- Psychomotor Performance
- Psychotic Disorders
- Pulmonary Disease, Chronic Obstructive
- Recurrence
- Respiratory Distress Syndrome, Newborn
- Respiratory Insufficiency
- Retinal Diseases
- Schizophrenia
- Schizophrenia
- Schizophrenia, Paranoid
- Schizophrenic Psychology
- Sclerosis
- Skin Neoplasms
- Sleep
- Sleep Stages
- Sleep, REM
- Stomach Neoplasms
- Stomach Ulcer
- Stroke
- Thrombocytopenia
- Tobacco Use Disorder
- Tremor
- Tuberculosis
- Tuberculosis, Pulmonary
- Urinary Bladder Neoplasms
- Urogenital Neoplasms
- Urologic Neoplasms
- Vasculitis
- Vision Disorders
- Vomiting
- Water Intoxication
- Weight Gain
- Werner syndrome
Abnova的Abnova Diagnostics F蛋白表达系统基于小麦胚芽的真核翻译设备。小麦胚在浓缩干燥状态下储存所有翻译成分，一旦发芽就准备好进行蛋白质合成。常规的小麦胚芽提取物包含RNA N-糖苷酶三丁酸酯和其他翻译抑制剂，例如硫蛋白，核糖核酸酶，脱氧核糖核酸酶和蛋白酶。这些抑制剂来自胚乳。大量洗涤小麦胚芽以消除胚乳污染物已导致提取物具有高度的稳定性和活性。通过将具有5'cap和多（RSA）尾巴的mRNA与该提取物与专有脂质体结合使用，进行体外翻译反应产生足够量的膜蛋白，该膜蛋白被脂质体捕获，导致正确的构象和生物学功能必不可少的折叠。该系统相对于普遍使用的蛋白质表达平台（例如大肠杆菌，昆虫细胞和哺乳动物细胞）具有明显优势，这些平台都是体内系统，并且在细胞膜的约束下导致产量和稳定性低。此外，体外小麦胚芽系统适于自动化以用于高通量小分子以及生物学筛选和表征。
