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商品描述
MAPK (p44) ERK1 Antibody
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Product Description | Affinity purified rabbit polyclonal p44 MAPK antibody is developed using the C-terminal peptide of human MAPK (ERK1). |  Western blot analysis of mouse brain extract (B) and spleen extract (A) with ICP9810. | |
Species | Rabbit | ||
Formulation | 250 µg/mL in TBS, 50% glycerol, 0.01% NaN3 | ||
Immunogen | Human p44 ERK1 C-terminal peptide-KLH conjugates | ||
Purification | The antibody was affinity purified with the p44 ERK1 C-terminal peptide on agarose. | ||
Specificity | The antibody recognizes p44 ERK1 of human, rat, bovine, mouse and rabbit. There is a slight cross reaction with p42 ERK2. | ||
Applications | ELISA; WB; IP | ||
Scientific Description | One of the members of mitogen-activated protein kinases is called P44 MAP Kinase (Erk1). It participates in cell growth and differentiation. [1,2] By phosphorylating transcription factors, (e., ELK-1), P44 MAP kinase regulates meiosis and mitosis of the cell. In the case of human MAP kinase, Erk1 activates Elk-1 through phosphorylation of threonine 202 and tyrosine 204. It is also known that Erk1 autophosphorylates tyrosine. [3] | ||
Storage & Stability | Product is stable for several weeks at 4°C. For extended storage, store product at -20°C. Expiration date is one year from date of shipping if stored properly. | ||
Product Specific References | 1. Mol Cell Biol.1993.13: 4679–4690.doi:10.1128/MCB.13.8.46792. Cell.1995. 80: 179–185.doi:10.1016/0092-8674(95)90401-83. EMBO J. 1991. 10: 885–892. |
