Product IDI7341Cas No. 54-85-3Purity ≥98%

• Description
• Product Info
• Shipping and Storage
• Downloads
• References

Description

Isoniazid is an antibacterial compound that displays efficacy against Mycobacterium and is clinically used to treat tuberculosis. Isoniazid inhibits InhA, an NADH-dependent enoyl-coA reductase.

Product Info

Cas No.PurityFormulaFormula Wt.Chemical NameIUPAC NameSynonymMelting PointSolubilityAppearance

54-85-3

≥98%

C6H7N3O

137.14

4-Pyridinecarboxylic acid, hydrazide

pyridine-4-carbohydrazide

Isonicotinoylhydrazine; Rimitsid; Tubazid; Cotinazin; Dinacrin; Ditubin; Hycozid.

170-173°C

Soluble in water (125 mg/mL, DMSO, methanol and ethanol (20 mg/mL).

White Crystal Powder

Shipping and Storage

Store TempShip Temp

Ambient

Ambient

Downloads

Info Sheet

I7341 Info Sheet PDF

References

Bernardes-Génisson V, Deraeve C, Chollet A, et al. Isoniazid: an update on the multiple mechanisms for a singular action. Curr Med Chem. 2013;20(35):4370-85. PMID: 23931278.

Argyrou A, Vetting MW, Blanchard JS. New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP. J Am Chem Soc. 2007 Aug 8;129(31):9582-3. PMID: 17636923.

Oliveira JS, Vasconcelos IB, Moreira IS, et al. Enoyl reductases as targets for the development of anti-tubercular and anti-malarial agents. Curr Drug Targets. 2007 Mar;8(3):399-411. PMID: 17348833.

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