品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
蚂蚁淘在线 / 品牌中心 / Cellagen / Cellagentech/TMC114 (Darunavir) | HIV-1 protease inhibitor/C8114-5/5 mg (powder)
商品描述
ProductDescription
DarunavirEthanolate(TMC114),aphenylalaninemimic,isapotentinhibitorofHIV-1proteasewithEC50activityagainstthewildtypeIIIBstrainof4nMandanaverageEC50activityagainstmutantproteaseinhibitorstrainsM1-M5of5nM.[1]FurThermore,fof150proteaseinhibitor-resistantvirusestested,75%wereinhibitedbydarunavirwithaEC50of
Darunavirexhibitsnocytotoxicityatconcentrationsupto100uMandhasbeenshowntobesynergisticwithavarietyofotherproteaseinhibitorsandreversetranscriptaseinhibitors.[3]
Technicalinformation:
| ChemicalFormula: | C27H37N3O7S.C2H5OH | |
| CAS#: | 635728-49-3 | |
| MolecularWeight: | 593.73 | |
| Purity: >98% | ||
| Appearance: | White | |
| ChemicalName: | N-[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamicacid(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ylestercompd.withethanol | |
| Solubility: | Upto100mMinDMSO | |
| Synonyms: | TMC114,635728-49-3,DarunavirEthanolate,Darunavir,Prezista |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | Surlerauxetal.,DiscoveryandSelectionofTMC114,aNextGenerationHIV-1ProteaseInhibitor.J.Med.Chem.2005,48,1813-1822.PubmedID:15771427 |
| 2. | Molinaetal.,Darunavir(TMC114):anewHIV-1proteaseinhibitor.ExpertOpin.Pharmacother.2007,8(12),1951-1964.PubmedID:17696796 |
| 3. | DeMeyeretal.,TMC114,aNovelHumanImmunodeficiencyVirusType1ProteaseInhibitorActiveagainstProteaseInhibitor-ResistantVirsues,IncludingaBroadRangeofClinicalIsolates.Antimicrob.Agents.Chemother.2005,49(6),2314-2321. |
Cellagen的ChamQ SYBR qPCR预混液（无ROX）| Q321产品描述ChamQSYBR®qPCR预混液（Vazyme，＃Q321）由香槟Taq DNA聚合酶（Vazyme，＃P122）通过抗体修饰的热启动激活技术保护，是专为基于SYBR Green I的定量PCR（qPCR）设计的。ChamQSYBR®qPCR Master Mix的优化缓冲液系统中的独特因素（即促进特异性的Exactor）大大提高了其灵敏度和特异性。该混合物以2倍反应浓度制备，可直接用于鲁棒性低模板qPCR，具有高灵敏度，特异性和可靠性。优点特异性+敏感性的最佳组合。独特的抗体修饰的热启动taq，具有独特的特异性促进因子。Mg2 +和染料的最佳浓度。
