品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
ProductDescription
Sitagliptin(alsonamedMK-0431andmarketedasJanuvia)isacompetitiveinhibitoroftheenzymedipeptidylpeptidase4(DPP-4).Sitagliptincanincreaseincretinlevels(GLP-1andGIP),whichinhibitglucagonrelease,whichinturnincreasesinsulinsecretion,decreasesgastricemptying,anddecreasesbloodglucoselevels.
Technicalinformation:
| ChemicalFormula: | C16H15F6N5O | |
| CAS#: | 486460-32-6 | |
| MolecularWeight: | 407.31 | |
| Purity: | >98% | |
| Appearance: | Whitesolid | |
| ChemicalName: | (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one | |
| Solubility: | Upto100mMinDMSO |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storage:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | HermanGA,etal.Pharmacokineticsandpharmacodynamicsofsitagliptin,aninhibitorofdipeptidylpeptidaseIV,inhealthysubjects:resultsfromtworandomized,double-blind,placebo-controlledstudieswithsingleoraldoses.ClinPharmacolTher2005;78(6):675–88. |
| 2. | HermanGA,etal.PharmacokineticsandpharmacodynamiceffectsoftheoralDPP-4inhibitorsitagliptininmiddle-agedobesesubjects.JClinPharmacol2006;46(8):876–86. |
| 3. | LeeB,etal.Pharmacokinetic,pharmacodynamic,andefficacyprofilesofalogliptin,anovelinhibitorofdipeptidylpeptidase-4,inrats,dogs,andmonkeys.EurJPharmacol.2008;589(1-3):306-14 |
Cellagen的ChamQ SYBR qPCR预混液（无ROX）| Q321产品描述ChamQSYBR®qPCR预混液（Vazyme，＃Q321）由香槟Taq DNA聚合酶（Vazyme，＃P122）通过抗体修饰的热启动激活技术保护，是专为基于SYBR Green I的定量PCR（qPCR）设计的。ChamQSYBR®qPCR Master Mix的优化缓冲液系统中的独特因素（即促进特异性的Exactor）大大提高了其灵敏度和特异性。该混合物以2倍反应浓度制备，可直接用于鲁棒性低模板qPCR，具有高灵敏度，特异性和可靠性。优点特异性+敏感性的最佳组合。独特的抗体修饰的热启动taq，具有独特的特异性促进因子。Mg2 +和染料的最佳浓度。
