ProductDescription
RO4929097isapotentandselectivesmallmoleculeinhibitorofγ-secretase(IC50=4nM),producinginhibitoryactivityofNotchsignalingintumorcells.ItinhibitsNotchprocessingintumorcellsasmeasuredbythereductionofintracellularNotchexpressionbyWesternblot.ThisleadstoreducedexpressionoftheNotchtranscriptionaltargetgeneHes1.RO4929097doesnotblocktumorcellproliferationorinduceapoptosisbutinsteadproducesalesstransformed,flattened,slower-growingphenotype.CurrentitisinphaseIstudyinpatientswithadvancedsolidtumors.
ProductCitation
NOTE:UnderlicensingagreementwithHoffmann-LaRocheLtd,thisproductistobeusedforinvitrostudyonly.
Technicalinformation:
| ChemicalFormula: | C22H20F5N3O3 | |
| CAS#: | 847925-91-1 | |
| MolecularWeight: | 469.40 | |
| Purity: | >98% | |
| Appearance: | Whitesolid | |
| ChemicalName: | 2,2-dimethyl-N-((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N′-(2,2,3,3,3-pentafluoro-propyl)-malonamide | |
| Solubility: | Upto50mMinDMSO |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storage:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | LuistroL,HeWetal.Preclinicalprofileofapotentgamma-secretaseinhibitortargetingnotchsignalingwithinvivoefficacyandpharmacodynamicproperties.CancerRes.2009;69(19):7672-80. |
Cellagen的ChamQ SYBR qPCR预混液（无ROX）| Q321产品描述ChamQSYBR®qPCR预混液（Vazyme，＃Q321）由香槟Taq DNA聚合酶（Vazyme，＃P122）通过抗体修饰的热启动激活技术保护，是专为基于SYBR Green I的定量PCR（qPCR）设计的。ChamQSYBR®qPCR Master Mix的优化缓冲液系统中的独特因素（即促进特异性的Exactor）大大提高了其灵敏度和特异性。该混合物以2倍反应浓度制备，可直接用于鲁棒性低模板qPCR，具有高灵敏度，特异性和可靠性。优点特异性+敏感性的最佳组合。独特的抗体修饰的热启动taq，具有独特的特异性促进因子。Mg2 +和染料的最佳浓度。
