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蚂蚁淘在线 / 品牌中心 / Cellagen / Cellagentech/RO318959 (Saquinavir) | HIV-1 protease inhibitor/C7318-2s/2 mg (10 mM solution in DMSO)
商品描述
ProductDescription
Saquinavirisadecahydroisoquinoline-based,selectiveinhibitorofasparticproteaseencodedbyHIVwithanIC50rangeof0.5-6.0nMandIC90rangeof6.0-30.0nM.[1]BindinginhibitionconstantsforsaquinaviragainstHIV-1andHIV-2are0.12nMand
AntiviralpotencyofsaquinavirwereshowninJMcellsinfectedwithHIV-1strainGB8withaIC50of2.5nM.[2]Similarly,andIC50of2nMwasobtainedagainstHIV-1(strainRF)inC8166cells.
SaquinavirwasshowntobeasubstrateforP-glycoproteintransporterprotein,affectingintracellularconcentrationsandbioavailABIlity.[3]
Technicalinformation:
| ChemicalFormula: | C38H50N6O5 | |
| CAS#: | 127779-20-8 | |
| MolecularWeight: | 670.84 | |
| Purity: | >98% | |
| Appearance: | White | |
| ChemicalName: | (2S)-N-[(2S,3R)-4-[(3S)-3-(tert-butylcarbamoyl)-decahydroisoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinolin-2-ylformamido)butanediamide | |
| Solubility: | Upto22mMinDMSO | |
| Synonyms: | RO318959,RO-31-8959,saguinavir,Fortovase,Invirase |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | Craigetal.,AntiviralpropertiesofRo31-8959,aninhibitorofhumanimmunodeficiencyvirus(HIV)proteinase.AnvitiralRes.1991,16,295-395.PubmedID:1810306 |
| 2. | Robertsetal.,Rationaldesignofpeptide-basedHIVproteinaseinhibitors.Science,1990,248,358-361.PubmedID:2183354 |
| 3. | Kimetal.,Saquinavir,anHIVproteaseinhibitor,istransportedbyP-glycoprotein.J.Pharmacol.Exp.Ther.1998,286(3),1439-1445.PubmedID:9732409 |
Cellagen的ChamQ SYBR qPCR预混液（无ROX）| Q321产品描述ChamQSYBR®qPCR预混液（Vazyme，＃Q321）由香槟Taq DNA聚合酶（Vazyme，＃P122）通过抗体修饰的热启动激活技术保护，是专为基于SYBR Green I的定量PCR（qPCR）设计的。ChamQSYBR®qPCR Master Mix的优化缓冲液系统中的独特因素（即促进特异性的Exactor）大大提高了其灵敏度和特异性。该混合物以2倍反应浓度制备，可直接用于鲁棒性低模板qPCR，具有高灵敏度，特异性和可靠性。优点特异性+敏感性的最佳组合。独特的抗体修饰的热启动taq，具有独特的特异性促进因子。Mg2 +和染料的最佳浓度。
