ProductDescription
Rivaroxabanisanorally-bioavailable,oxazolidinone-basedinhibitor(Ki=0.4nM)offactorXa,thefactorinthebloodcoagulationpathwayleADIngtothrombingenerationandclotformation.[1]Itisapprovedforbothdeepveinthrombosisandpulmonaryembolism.Itis>10000-foldselectiveforfXaoverotherBIOLOGicallyrelevantserineproteases.Rivaroxabaninhibitsprothrombinase-bound(IC50=2.1nM,andclot-associatedfactorXa(IC50=75nM)inadose-dependentmanner.[1]
Invivo,RivaroxabaninhibitsendogenousfXamorepotentlyinhumanandrabbitplasma(IC50=21nM)thaninratplasma(IC50=290nM).[2]Inhumanplasma,PTandaPTTweredoubledat0.23and0.69uM,respectively.
Technicalinformation:
| ChemicalFormula: | C19H18ClN3O5S | |
| CAS#: | 366789-02-8 | |
| MolecularWeight: | 435.88 | |
| Purity: | >99% | |
| Appearance: | White | |
| ChemicalName: | (S)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide | |
| Solubility: | Upto100mMinDMSO | |
| Synonyms: | Rivaroxaban,Xarelto,BAY-59-7939,BAY59-7939,BAY59-7939 |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | Perzbornetal.,Rivaroxaban:aneworalfactorXainhibitor.Arterioscler.Thromb.Vasc.Biol.2010,30,376-381.PubmedID:20139357 |
| 2. | Perzbornetal.,InvitroandinvivostudiesofthenovelantithromboticagentBAY59-7939--anoral,directFactorXainhibitor.J.Thromb.Haemost.2005,3(3),514-521.PubmedID:15748242 |
Cellagen的ChamQ SYBR qPCR预混液（无ROX）| Q321产品描述ChamQSYBR®qPCR预混液（Vazyme，＃Q321）由香槟Taq DNA聚合酶（Vazyme，＃P122）通过抗体修饰的热启动激活技术保护，是专为基于SYBR Green I的定量PCR（qPCR）设计的。ChamQSYBR®qPCR Master Mix的优化缓冲液系统中的独特因素（即促进特异性的Exactor）大大提高了其灵敏度和特异性。该混合物以2倍反应浓度制备，可直接用于鲁棒性低模板qPCR，具有高灵敏度，特异性和可靠性。优点特异性+敏感性的最佳组合。独特的抗体修饰的热启动taq，具有独特的特异性促进因子。Mg2 +和染料的最佳浓度。
