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商品描述
ProductDescription
LY2886721isanorally-available,furothiazine-basedinhibitorofb-amyloidproteincleavingenzyme(BACE)forthetreatmentofAlzheimer"sdisease.[1]ItinhibitsrecombinanthBACE1withanIC50of20nM.[2]Incellularassays,LY2886721inhibitsAbetawithanIC50rangeof10-19nM.OraladmiNISTrationofLY2886721toPDAPPmiceproduceddose-dependentreductionsinbrainAbeta,C99,andsAPPbeta.[2]
Technicalinformation:
| ChemicalFormula: | C18H16F2N4O2S | |
| CAS#: | 1262036-50-9 | |
| MolecularWeight: | 390.41 | |
| Purity: | >98% | |
| Appearance: | White | |
| ChemicalName: | N-(3-((4aS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide | |
| Solubility: | Upto20mMinDMSO | |
| Synonyms: | LY-2886721,LY2886721,LY2886721 |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | Alzheimer"sDiseaseResearchUnitStudiessynopsis(April1,2012) |
| 2. | AlzheimerAssocationInternationalConference,2012,OralSessions(O1-06-03):"PreclinicalCharacterizationofLY2886721:ABACE1inhibitorinclinicaldevelopmetnforearlyAlzheimer"sdisease" |
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