Bulk Adalimumab Biosimilar – Research Grade
Product Benefits:
ichorbio’s Adalimumab Biosimilar – Research Grade is manufactured in a cGMP compliant facility. ichorbio offers Amazon vouchers or donations to the NC3Rs for reviews of this product: click here for more information. ichorbio: the best antibodies for in vivo research.
Size:
ichorbio’s research grade adalimumab biosimilar is available in the following sizes:5mg, 10mg, 20mg, 50mgichorbio regularly manufactures bulk multi-gram amounts of our adalimumab biosimilar – please contact us for pricing.
Target:
TNF alpha
Clone:
n/a
Isotype:
IgG1 kappa
Other Names:
Cachectin, TNFa, Tumor necrosis factor ligand superfamily member 2, Tnfsf2
Host:
Humanized
Species Reactivity:
Human
Specificity:
Detects human TNF alpha. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Adalimumab.
Purification Method:
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background:
Adalimumab biosimilar is a recombinant human IgG1 monoclonal antibody specific for human tumor necrosis factor (TNF), was created using phage display technology resulting in an antibody with human derived heavy and light chain variable regions and human IgG1:k constant regions. Adalimumab biosimilar is produced by recombinant DNA technology in a mammalian cell (Chinese Hamster Ovary) expression system and is purified by a process that includes specific viral inactivation and removal steps. It consists of 1330 amino acids and has a molecular weight of approximately 148 kilodaltons.
Concentration:
1.0 – 5.0 mg/ml
Formulation:
0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.
Purity:
>95% by SDS-PAGE and HPLC
Endotoxin:
≤ 0.75 EU/mg as determined by the LAL method
Storage:
Adalimumab Biosimilar is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Applications:
Functional Assays
Application Notes:
Each investigator should determine their own optimal working dilution for specific applications.
Use:
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