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商品描述
| Source | M.W. | 599 | CAS No. | 364590-63-6 | |
|---|---|---|---|---|---|
| Structural Info | C28H28ClN3OS·2HCl·2H2O | ||||
| Formulation | Solution. 2.5 mg/mL in DMSO (4 mM) | ||||
| Reconstitution | The compound has been dissolved in DMSO. | ||||
| Stability | The powder is stable for at least 2 year if stored at-20 °C.The dissolved compound isstable for at least 1 month at 4 °C, but should be stored in aliquots at-20 °C for longer term. Protectfrom light. | ||||
| Purity | Greater than 98% as determined by LC/MS analysis.LC/MS and/or NMR data available upon request. | ||||
| Biological Activity | In a cell-based assay measuring the activation of the Gli-1 reporter gene, this compound gives EC50 of 2-10 nM. | ||||
| Country of Origin | |||||
SAG is a highly potent agonist of SMO (smoothened). This small molecule compound activates thehedgehog pathway by directly binding to SMO. Note: in the Gli-1 reporter gene assay, SAG acts as an activator atconcentrations from approximately 1 nM to 1 uM, but as an inhibitor atconcentrations high than 1 uM.Ref: Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA99, 14071
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