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Stemrd/Thiazovivin/5 mg/THIA-005

价格
¥3780.00
货号:THIA-005
浏览量:127
品牌:Stemrd
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商品描述
SourceM.W.311.36CAS No.1226056-71-8
Structural InfoThiazovivin
FormulationPowder
ReconstitutionBefore reconstitution, we recommend a brief spin todrive down any material dislodged from the bottom of the tube. The compound is soluble in DMSO.
StabilityThe powder is stable for at least 1 year if stored at-20 °C.The dissolved compound isstable for at least 1 month at 4 °C, but should be stored in aliquots at-20 °C for longer term. Protectfrom light.
PurityGreater than 99% as determined by LC/MS analysis.LC/MS and/or NMR data available upon request.
Biological ActivityTested active for culturing human iPS cells in serum-free medium on Matrigel coated plates.
Country of OriginUSA

Thiazovivin,N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide, is a selectiveinhibitor of Rho-associated kinase (ROCK). It protects human ES cells from death in the absence of ECM byregulating E-cadherin mediated cell-cell interaction.Thiazovivin, in combination with inhibitorsof the TGF-beta receptor and the MEK kinases, improves reprogramming efficiencydramatically.Ref: Lin, T., et al. (2009) Achemical platform for improved induction of human iPSCs. Nature Methods. 6(11):805.

Product Sheet
Stemrd的Y-27632,(1R,4r)-4-((R)-1-氨乙基)-N-(吡啶-4-基)环己烷-羧酰胺-2HCl,是一种Rho相关激酶(ROCK)抑制剂。Y27632已被证明可以防止凋亡,并提高解离的人类胚胎干(ES)细胞的存活率和克隆效率,而不会影响其多能性。