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商品描述
| Source | M.W. | 520.6 | CAS No. | 483367-10-8 | |
|---|---|---|---|---|---|
| Structural Info | C31H32N6O2 | ||||
| Formulation | Powder | ||||
| Reconstitution | Before reconstitution, werecommend a brief spin to drive down any material dislodged from the bottom ofthe tube. The compound is soluble inDMSO. | ||||
| Stability | The powder is stable for atleast 2 year if stored at -20 °C.The dissolved compound is stable for at least 1 month at 4 °C, butshould be stored in aliquots at -20 °C for longer term. Protect from light. | ||||
| Purity | Greater than 98% as determined by LC/MS analysis.LC/MS and/or NMR data available upon request. | ||||
| Biological Activity | In a cell-based assay measuring the activation of the Gli-1 reporter gene, this compound gives EC50 of 1.0 uM. | ||||
| Country of Origin | USA | ||||
Purmorphamine is an agonistof SMO (smoothened). This small moleculecompound activates the hedgehog pathway by directly binding to SMO. It has been shown to induce osteogenesis ofmesenchymal stem cells.Ref: Wu, X., et al. 2004. Chem. Biol. 11:1229; Sinha, S. Chen, J.K. 2006.Nat. Chem. Biol. 2: 29
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