AlumVax Hydroxide is wet gel (colloidal) of aluminum hydroxide 2%, provided as a ready-to-use suspension.
Aluminum hydroxide is the most common adjuvant used in approved prophylactic vaccines because of its excellent safety profile and ability to enhance protective humoral immune response. Since more than 80 years, it has been observed that aluminium compounds act by a depot effect and also by direct activation of the immune cells. Adsorption or entrapment of antigens in aggregates through hydrophobic and electrostatic interactions favors a high local antigen concentration and improved uptake by antigen presentating cells (APC).
AlumVax hydroxide is a crystalline aluminum oxyhydroxide that is positively charged at physiological pH (pI=11), suitable for adsorption of negatively charged, acidic proteins (such as albumin).
Sizes:
50 mL
250 mL
Also available in bulk, please contact us : order@ozbiosciences.com
Storage: Room Temperature
Shipping conditions: Room Temperature
Please log in or register to see the prices for your country
OZ Biosciences的VaxOZ佐剂非常适合作为金标准参照物和任何免疫实验。也可以使用您自己的免疫刺激剂来定制它们。当前，佐剂仍然是提高常规和下一代疫苗效率的最重要策略。遗传佐剂是与特定抗原结合使用的免疫学试剂，可增强免疫反应。直接后果是与仅使用抗原相比，会产生更多的抗体和更长的免疫力，从而使疫苗所需的抗原剂量降至最低。特别是，基于DOTAP（1,2-油酰基--3-三甲基铵-丙烷）的阳离子脂质可诱导树突状细胞成熟，然后运输至引流淋巴结以激活抗原特异性T细胞。疫苗佐剂OZ生物科学VaxOZ佐剂是体内制造和质量控制的产品，仅用于研究目的。- AlumVax氢氧化物 / 磷酸盐，两个古典铝基佐剂- IFAVax， 不完全弗氏佐剂- CFAVax，完全弗氏佐剂- SqualVax，一个纳米油包水乳液- CaLiVax-DOTAP， 对于脂质体介导的DNA或蛋白质疫苗基于阳离子脂质的组合物。
