In vivo SilenceMag™ is a rapid, simple and highly efficient method dedicated to transfect small RNA (siRNA, miRNA) into target cells/tissue in vivo. It combines magnetic nanoparticles and small RNA that will be retained after injection at the magnetically targeted site. This targeted delivery method minimizes systemic distribution, increases gene targeted inactivation and reduces toxicity. Furthermore, the magnetic forces enhance the uptake of magnetic nanoparticles by the target tissue, and thus improve the efficiency of silencing.

 

This allows decreasing the required process time of delivery to few minutes which is crucial for improvement of in vivo small RNA delivery. In vivo SilenceMag™ is designed to meet in vivo grade quality.

 

In vivo SilenceMag™ benefits:

• Increased silencing efficiency
• Targeted process (magnetically-driven)
• Reduction of the systemic dissemination of siRNA/miRNA during injection
• Reduction of the siRNA/miRNA doses
• Work under non permissive conditions (hypothermia, physiological flow conditions)
• Penetration of the siRNA/miRNA into tissues
• Minimized toxicity

 

 

Storage: +4°C

Shipping Conditions: Room temperature

 

• NB: This reagent needs to be used with a magnet

OZ Biosciences的VaxOZ佐剂非常适合作为金标准参照物和任何免疫实验。也可以使用您自己的免疫刺激剂来定制它们。当前，佐剂仍然是提高常规和下一代疫苗效率的最重要策略。遗传佐剂是与特定抗原结合使用的免疫学试剂，可增强免疫反应。直接后果是与仅使用抗原相比，会产生更多的抗体和更长的免疫力，从而使疫苗所需的抗原剂量降至最低。特别是，基于DOTAP（1,2-油酰基--3-三甲基铵-丙烷）的阳离子脂质可诱导树突状细胞成熟，然后运输至引流淋巴结以激活抗原特异性T细胞。疫苗佐剂OZ生物科学VaxOZ佐剂是体内制造和质量控制的产品，仅用于研究目的。- AlumVax氢氧化物 / 磷酸盐，两个古典铝基佐剂- IFAVax， 不完全弗氏佐剂- CFAVax，完全弗氏佐剂- SqualVax，一个纳米油包水乳液-  CaLiVax-DOTAP， 对于脂质体介导的DNA或蛋白质疫苗基于阳离子脂质的组合物。