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4000-520-616 / 18915418616
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0512-67156496
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商品描述
BIOLOGICAL INFORMATION
DescriptionThe chimeric peptide M35 [galanin (1-13)-bradykinin(2-9) amide] is a high-affinity galanin receptor ligand acting as a galanin receptor antagonist in the rat spinal cord, rat hippocampus and isolated mouse pancreatic islets. The radiolabelled M35 and performed equilibrium binding studies with [125I] M35 on the rat pancreatic beta-cell line Rin m 5F. Galanin displaces [125I] M35 with the same affinity (KD = 1 nM) as it displaces [125I] galanin. Displacement of [125I] galanin by M35 from Rin m 5F cell membranes shows the presence of two binding sites for M35 with KD-values of 0.3 +/- 0.1 nM and 0.52 +/- 0.03 µM, respectively.
ApplicationMelanocortin
NoteFor research only, not for human use!
CHEMICAL INFORMATION
CAT No.ONP10571
CAS No.N/A
NameGalanin Receptor Ligand M35
Chemical NameGalanin-Receptor-Ligand-M35
Purity≥98%
SynonymsN/A
FormulaC107H153N27O26
Molecular Weight2233.6
One Letter CodeGWTLNSAGYLLGPPPGFSPFR-NH2
Three Letter CodeGLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-PRO-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG-NH2
SMILESN/A
InChI KeyN/A
SourceSynthetic
FormDry Powder
ColorWhite
SolubilityN/A
SHIPPING & STORAGE
Storage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
ShippingIce Pack
Stability≥ 2 years
REFERENCES & CITATIONS
1.Kwong SM, et al. Replication Control of Staphylococcal Multiresistance Plasmid pSK41: an Antisense RNA Mediates Dual-Level Regulation of Rep Expression. J.Bacteriol. Jun 2006; 188(12): 4404-4412.
2.Tomas A, et al. Regulation of pancreatic {beta}-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway. J.Cell.Sci. May 2006; 119(10): 2156-2167.
3. Biophys.J. Jun 2006; 90(12): 4618-4629.
DOCUMENTATIONS
- COA
- Data sheet
- MS
- RP-HPLC
- MSDS
- Handling Instruction
PROMOTIONS & EVENTS
