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商品描述
BIOLOGICAL INFORMATION
DescriptionPGLa is an antibiotic peptide found in frog skin. As a member of the magainin family it assumes an amphiphilic α-helical structure upon membrane binding. The cationic peptide has a high affinity for bacterial membranes and is able to permeabilize them.
ApplicationMelanocortin
NoteFor research only, not for human use!
CHEMICAL INFORMATION
CAT No.ONP10046
CAS No.102068-15-5
NamePGLa
Chemical NamePGLa
Purity≥98%
SynonymsGla peptide; Pgl(a); Peptide-gly-leu-amide; (4-24)-Ply(a)
FormulaC88H162N26O22S
Molecular Weight1968.46
One Letter CodeGMASKAGAIAGKIAKVALKAL-NH2
Three Letter CodeGLY-MET-ALA-SER-LYS-ALA-GLY-ALA-ILE-ALA-GLY-LYS-ILE ALA-LYS-VAL-ALA-LEU-LYS-ALA-LEU-NH2
SMILESCCC(C)C(C(=O)NC(C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)N)NC(=O)C(C)NC(=O)CNC(=O)C(C)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)CN
InChI KeyPJRSUKFWFKUDTH-JWDJOUOUSA-N
SourceSynthetic
FormDry Powder
ColorWhite
SolubilityN/A
SHIPPING & STORAGE
Storage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
ShippingBlue Ice
Stability≥ 2 years
REFERENCES & CITATIONS
1.Wang Get al. Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. Antimicrob Agents Chemother 54:1343-6 (2010).
2.Hartmann Met al. Damage of the bacterial cell envelope by antimicrobial peptides gramicidin S and PGLa as revealed by transmission and scanning electron microscopy. Antimicrob Agents Chemother 54:3132-42 (2010).
3.Sun J & He W [Study on relationship of biodegradable properties of PGLA film in vivo and in vitro]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 21:717-20 (2004).
DOCUMENTATIONS
- COA
- Data sheet
- MS
- RP-HPLC
- MSDS
- Handling Instruction
PROMOTIONS & EVENTS
