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商品描述
BIOLOGICAL INFORMATION
DescriptionA decoy receptor, or sink receptor, is a receptor that binds a ligand, inhibiting it from binding to its normal receptor. For instance, the receptor VEGFR-1 can prevent vascular endothelial growth factor (VEGF) from binding to the VEGFR-2.When a prorenin-binding protein interacts with the “handle” region of the prorenin prosegment, the prorenin molecule undergoes a conformational change to an enzymatically active state (5). This phenomenon is called nonproteolytic activation.
ApplicationMelanocortin
NoteFor research only, not for human use!
CHEMICAL INFORMATION
CAT No.ONP10023
CAS No.N/A
NameHandle region peptide (HRP),rat
Chemical NameHandle-region-peptide-(HRP),rat
Purity≥98%
SynonymsN/A
FormulaN/A
Molecular Weight1184.54
One Letter CodeRILLKKMPSV
Three Letter CodeArg-Ile-Leu-Leu-Lys-Lys-Met-Pro-Ser-Val
SMILESN/A
InChI KeyN/A
SourceSynthetic
FormDry Powder
ColorWhite
SolubilityN/A
SHIPPING & STORAGE
Storage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
Stability≥ 2 years
REFERENCES & CITATIONS
1.Inhibition of diabetic nephropathy by a decoy peptide corresponding to the “handle” region for nonproteolytic activation of prorenin
2.Prorenin and Renin-Induced Extracellular Signal-Regulated Kinase 1/2 Activation in Monocytes Is Not Blocked by Aliskiren or the Handle-Region Peptide
3.(Pro)Renin Receptor Peptide Inhibitor “Handle-Region” Peptide Does Not Affect Hypertensive Nephrosclerosis in Goldblatt Rats
DOCUMENTATIONS
- COA
- Data sheet
- MS
- RP-HPLC
- MSDS
- Handling Instruction
PROMOTIONS & EVENTS
