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商品描述
BIOLOGICAL INFORMATION
DescriptionA soluble form of the Interleukin-6 receptor (IL-6R) was initially identified in the urine of healthy adult humans, in culture supernatants from HTLV-I positive T cell lines and in the serum of HIV-seropositive blood donors. These soluble receptors (Interleukin-6 receptor) may develop as a result of alternate splicing of the mRNA or as a result of proteolytic cleavage and release of the membrane-bound form of the receptor. Recombinant, Human IL-6 Soluble Receptor was produced by cloning the cDNA of the IL-6R and introducing a stop codon into the cDNA sequence immediately preceding the transmembrane domain. This was followed by infection of Sf 21 insect cells with recombinant baculovirus encoding the sequence for the truncated receptor. The IL-6 soluble receptor is 339 amino acid residues in length. IL-6 soluble receptor may serve to transport IL-6, protecting IL-6 from proteolysis. Alternatively, the IL-6 soluble receptor may act as an inhibitory agent to localize the activity of IL-6 or to bind IL-6 that is not bound to cell surface receptors. The bioactivity of IL-6 increases after binding to the soluble IL-6 receptor.
ApplicationMelanocortin
NoteFor research only, not for human use!
CHEMICAL INFORMATION
CAT No.ONP10765
CAS No.N/A
NameInterleukin (IL)-6 Receptor
Chemical NameInterleukin-(IL)-6-Receptor
Purity≥98%
SynonymsIL-6 RIL6R peptide
FormulaC51H85N13O21
Molecular Weight1216.3
One Letter CodeTSLPVQDSSSVP
Three Letter CodeTHR-SER-LEU-PRO-VAL-GLN-ASP-SER-SER-SER-VAL-PRO
SMILESN/A
InChI KeyN/A
SourceSynthetic
FormDry Powder
ColorWhite
SolubilityN/A
SHIPPING & STORAGE
Storage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
ShippingIce Pack
Stability≥ 2 years
REFERENCES & CITATIONS
1.Karaduman M, et al. Leptin, soluble interleukin-6 receptor, C-reactive protein and soluble vascular cell adhesion molecule-1 levels in human coronary atherosclerotic plaque. Clin. Exp. Immunol. Mar 2006; 143(3): 452-457.
2.Zhang PL, et al. Increased myelinating capacity of embryonic stem cell derived oligodendrocyte precursors after treatment by interleukin-6/soluble interleukin-6 receptor fusion protein. Mol. Cell. Neurosci. Mar 2006; 31(3): 387-398.
3.Maggio M, et al. Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men. J. Clin. Endocrinol. Metab. Jan 2006; 91(1): 345-347.
DOCUMENTATIONS
- COA
- Data sheet
- MS
- RP-HPLC
- MSDS
- Handling Instruction
PROMOTIONS & EVENTS
