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商品描述
BIOLOGICAL INFORMATION
DescriptionThe orphan receptor GPR14 has been found to be expressed predominantly in cardiovascular tissue and many serve as a receptor for urotensin II (human). Urotensin II (human) binds with high affinity to recombinant GPR14. It is found within both vascular and cardiac tissue. Urotensin II vasoconstrictive potency is reported to be an order of magnitude greater than that of endothelin-1 (ET-1), which would make it the most potent mammalian vasoconstrictor identified to date. Recently, our research data has shown that urotensin II is involved in the development of rat cardiac hypertrophy: Contractile response to human U II in rat and human pulmonary arteries was increased by endothelial factors, vascular tone, and the onset of pulmonary hypertension.
ApplicationMelanocortin
NoteFor research only, not for human use!
CHEMICAL INFORMATION
CAT No.ONP10875
CAS No.251293-28-4
NameUrotensin II, human
Chemical NameUrotensin-II,-human
Purity≥98%
SynonymsU II UrotensinII; Urotensin 2; Urotensin2
FormulaC64H85N13O18S2
Molecular WeightN/A
One Letter CodeETPDCFWKYCV HCl (Disulfide bridge: 5-10)
Three Letter CodeH-Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val-OH HCl (Disulfide bridge: 5-10)
SMILESCC(C)C(C(=O)O)NC(=O)C1CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)CCCCN)CC3=CNC4=CC=CC=C43)CC5=CC=CC=C5)NC(=O)C(CC(=O)O)NC(=O)C6CCCN6C(=O)C(C(C)O)NC(=O)C(CCC(=O)O)N
InChI KeyHFNHAPQMXICKCF-WCNHMZSTSA-N
SourceSynthetic
FormDry Powder
ColorWhite
SolubilityN/A
SHIPPING & STORAGE
Storage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
ShippingIce Pack
Stability≥ 2 years
REFERENCES & CITATIONS
1.Coulouarn et al (1998) Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurones of the spinal cord. Proc.Natl.Acad.Sci.U.S.A. 95 15803 PMID: 9861051
2.Maguire and Davenport (2002) Is urotensin-II the new endothelin? Br.J.Pharmacol 137 579 PMID: 12381671
3.Nothacker et al (1999) Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction. Nat.Cell.Biol. 1 383 PMID: 10559967
DOCUMENTATIONS
- COA
- Data sheet
- MS
- RP-HPLC
- MSDS
- Handling Instruction
PROMOTIONS & EVENTS
