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商品描述
BIOLOGICAL INFORMATION
DescriptionHistatin 5 is a human basic salivary peptide with strong fungicidal properties in vitro. To elucidate the mechanism of action, the effect of histatin 5 on the viability of Candida albicans cells was studied in relation to its membrane perturbing properties. It was found that both the killing activity and the membrane perturbing activity, studied by the influx of a DNA-specific marker propidium iodide, were inhibited by high salt conditions and by metabolic inhibitors, like sodium azide.
ApplicationMelanocortin
NoteFor research only, not for human use!
CHEMICAL INFORMATION
CAT No.ONP10035
CAS No.104339-66-4
NameHistatin 5
Chemical NameHistatin-5
Purity≥98%
SynonymsSalivary histatin 5; Histidine-rich peptide; Hsn-5
FormulaC133H195N51O33
Molecular Weight3036.29
One Letter CodeDSHAKRHHGYKRKFHEKHHSHRGY
Three Letter CodeASP-SER-HIS-ALA-LYS-ARG-HIS-HIS-GLY-TYR-LYS-ARG-LYS-PHE-HIS-GLU-LYS-HIS-HIS-SER-HIS-ARG-GLY-TYR
SMILESCC(C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CN=CN2)C(=O)NCC(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CC5=CN=CN5)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CC6=CN=CN6)C(=O)NC(CC7=CN=CN7)C(=O)NC(CO)C(=O)NC(CC8=CN=CN8)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CC9=CC=C(C=C9)O)C(=O)O)NC(=O)C(CC1=CN=CN1)NC(=O)C(CO)NC(=O)C(CC(=O)O)N
InChI KeyKSXBMTJGDUPBBN-VPKNIDFUSA-N
SourceSynthetic
FormDry Powder
ColorWhite
SolubilityN/A
SHIPPING & STORAGE
Storage4 degree ℃ for short term (weeks) and -20 degree ℃ for long term.
ShippingBlue Ice
Stability≥ 2 years
REFERENCES & CITATIONS
1.Konopka, K. et al. (2010). Susceptibility of Candida biofilms to histatin 5 and fluconazole. Antonie van Leeuwenhoek 97, 413.
2.Huo Let al. Antimicrobial and DNA-binding activities of the peptide fragments of human lactoferrin and histatin 5 against Streptococcus mutans. Arch Oral Biol 56:869-76 (2011).
3.Luque-Ortega JRet al. Human antimicrobial peptide histatin 5 is a cell-penetrating peptide targeting mitochondrial ATP synthesis in Leishmania. FASEB J 22:1817-28 (2008).
DOCUMENTATIONS
- COA
- Data sheet
- MS
- RP-HPLC
- MSDS
- Handling Instruction
PROMOTIONS & EVENTS
