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商品描述
β-Secretase Inhibitor 2
Sequence (1LC):
KTEEISEVN-Sta-VAEF-OH (Sta=Statine)
Sequence (3LC):
CONH2 - Lys - Thr - Glu - Glu - Ile - Ser - Glu - Val - Asn - Sta - Val - Ala - Glu - Phe - OH
Catalog :
10102-01
Unit:
1 mg
Price/Unit:
$176(For other quantities please Contact Us or call 972-420-8505)
Purity:
Purity > 95% by HPLC
Format:
Each vial contains lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt
Description:
Beta - Secretase Inhibitor 2, also called BACE1 (β-site of APP cleaving enzyme) or memapsin-2, is a amyloid precursor protein (APP) b-secretase from human brain cleaves full-length APP at the amino terminus of the amyloid b-protein (Ab) sequence, thus leading to the generation and extracellular release of b-cleaved soluble APP and a corresponding cell-associated carboxy-terminal fragment. The subsequent cleavage of the C-terminal fragment by g-secretase(s) leads to the formation of Ab. This new peptide represents a potent substrate analog inhibitor of APP b-secretase with IC50 = 30 nM.
C-terminus is amidated.
Storage:
-20°C
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Formula:
C73H118N16O27
M.W.:
1651.83
Reference/Citations:
- S.Sinha et al., Nature , 402, 537 (1999)
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