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商品描述
Product information "Ursodeoxycholic Acid (sodium salt)"
Ursodeoxycholic acid (UDCA) is a secondary bile acid formed via epimerization of chenodeoxycholic acid (CDCA, Cay-10011286). UDCA is also a metabolite of lithocholic acid (LCA, Cay-20253) in human liver microsomes. It inhibits taurocholic acid (Cay-16215) uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 µM. UDCA (50 µM) inhibits apoptosis induced by deoxycholic acid (DCA, Cay-20756, Cay-18231) or ethanol in primary rat hepatocytes. Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis.
| Keywords: | UDCA, (5beta)-3alpha,7beta-dihydroxy-cholan-24-oic acid, monosodium salt |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 15121-250 |
Properties
| Application: | Hydrophilic bile acid |
| MW: | 414.6 D |
| Formula: | C24H39O4 . Na |
| Purity: | >98% |
| Format: | Crystalline Solid |
Database Information
| CAS : | 2898-95-5| Find alternatives |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |  |
| H Phrases: | H315, H319, H335 |
| P Phrases: | P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution Our products are for laboratory research use only: Not for administration to humans!
