Anti-Pantophysin抗体
| 产品编号 | YB-7411R |
| 英文名称 | Pantophysin |
| 中文名称 | 突触素样蛋白1抗体 |
| 别名 | SYPL1_HUMAN; Synaptophysin-like protein 1; Pantophysin; SYPL1; H-SP1; SYPL. |
| 规格价格 | 100ul/1380元购买200ul/2200元购买大包装/询价 |
| 说明书 | 100ul200ul |
| 研究领域 | 细胞生物神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human,Mouse,Rat,Pig,Cow,Rabbit, |
| 产品应用 | WB=1:500-2000ELISA=1:500-1000IHC-P=1:400-800IHC-F=1:400-800IF=1:100-500（石蜡切片需做抗原修复）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user. |
| 分子量 | 29kDa |
| 细胞定位 | 细胞浆细胞膜 |
| 性状 | Lyophilized or Liquid |
| 浓度 | 1mg/ml |
| 免疫原 | KLH conjugated synthetic peptide derived from human Pantophysin:121-220/259 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储存液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background:The MARVEL domain is a 130 amino acid motif that contains four transmembrane helices, both of which have cytoplasmic N- and C-terminal regions. MARVEL domain-containing proteins are thought to participate in tight junction regulation, the biogenesis of vesicular transport carriers and in cholesterol-rich membrane apposition events. Pantophysin, also known as SYPL1 (synaptophysin-like protein 1) or H-SP1, is a 259 amino acid multi-pass membrane protein that localizes to melanosomes and vesicles, as well as to the cytoplasm, and contains one MARVEL domain. Expressed as multiple alternatively spliced isoforms, pantophysin is present in tissues throughout the body where it may play a role in vesicle trafficking and protein transport. The gene encoding pantophysin maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.Subcellular Location:Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity). Melanosome. Note=Cytoplasmic transport vesicles (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.Similarity:Belongs to the synaptophysin/synaptobrevin family.Contains 1 MARVEL domain.SWISS:Q16563Gene ID:6856Database links: Entrez Gene: 6856Human Entrez Gene: 19027Mouse Entrez Gene: 366595Rat SwissProt: Q16563Human SwissProt: O09117Mouse Unigene: 80919Human Unigene: 246304Mouse Unigene: 17193Rat Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 | ![](\"http://img.ebiomall.cn/images/sell/bs-7411R_01_small.jpg\") Tissue/cell: mouse colon tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;Incubation: Anti-Pantophysin Polyclonal Antibody, Unconjugated(bs-7411R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining |
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