Product overview

• NamePhorbol 12-myristate 13-acetate (PMA)
• Short descriptionPKC activator
• Biological description

  Protein kinase C (PKC) activator which associates to C1 domain. Structurally analogous to diacylglycerol. Induces ERK1/2 activation.

  Frequently used with ionomycin to stimulate intracellular cytokine production in T-cells.

  Facilitates long term potentiation in hippocampal neurons via δ and ε PKC binding sites.

  Also potentiates exocytosis and modulates vesicle fusion kinetics.

  Displays tumor promoting properties.

• Alternative namesPMA; TPA
• Biological actionActivator
• Purity>99%
• Our products in action1 citationSubmit Your Citation Now

Images

Properties

• Chemical name(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a ,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl tetradecanoate
• Molecular Weight616.83
• Chemical structure
• Molecular FormulaC₃₆H₅₆O₈
• CAS Number16561-29-8
• PubChem identifier27924
• SMILESCCCCCCCCCCCCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)C)O)C
• InChiInChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
• InChiKeyPHEDXBVPIONUQT-RGYGYFBISA-N
• MDL numberMFCD00036736

Storing and Using Your Product

• Storage instructions-20°C (desiccate)
• Solubility overviewSoluble in DMSO (100mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for Phorbol 12-myristate 13-acetate (PMA)

• Phorbol 12-myristate 13-acetate inhibits P-glycoprotein-mediated efflux of digoxin in MDCKII-MDR1 and Caco-2 cell monolayer models.

  Li YH et al (2014)Acta Pharmacol Sin 35(2) : 283-91. PubMedID: 24362330

• Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2.

  Jørgensen K et al (2005)Biochem Biophys Res Commun 329(1) : 266-74. PubMedID: 15721302

• Involvement of PKC alpha in PMA-induced facilitation of exocytosis and vesicle fusion in PC12 cells.

  Xue R et al (2009)Biochem Biophys Res Commun 380(2) : 371-6. PubMedID: 19250646

• Phorbol 12-Myristate 13-Acetate Enhances Long-Term Potentiation in the Hippocampus through Activation of Protein Kinase Cδ and ε.

  Kim EC et al (2013)Korean J Physiol Pharmacol 17(1) : 51-6. PubMedID: 23440225

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