• 货号：	PAM177929-Human
  供应商：	Acebiox
  数量：	1
  英文名：	Signaling by EGFR PCR Array
  保质期：	一年
  保存条件：	4℃避光保存
  规格：	96孔

  EGFR信号通路基因表达谱PCR芯片

  Signaling by EGFRGene Expression PCR Array

   

  EGFR 信号通路介绍

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  The epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational change that unmasks the dimerization interface in the extracellular domain of EGFR, leading to receptor homo- or heterodimerization at the cell surface. Dimerization of the extracellular regions of EGFR triggers additional conformational change of the cytoplasmic EGFR regions, enabling the kinase domains of two EGFR molecules to achieve the catalytically active conformation. Ligand activated EGFR dimers trans-autophosphorylate on tyrosine residues in the cytoplasmic tail of the receptor. Phosphorylated tyrosines serve as binding sites for the recruitment of signal transducers and activators of intracellular substrates, which then stimulate intracellular signal transduction cascades that are involved in regulating cellular proliferation, differentiation, and survival. Recruitment of complexes containing GRB2 and SOS1 to phosphorylated EGFR dimers either directly, through phosphotyrosine residues that serve as GRB2 docking sites, or indirectly, through SHC1 recruitment, promotes GDP to GTP exchange on RAS, resulting in the activation of RAF/MAP kinase cascade. Binding of complexes of GRB2 and GAB1 to phosphorylated EGFR dimers leads to formation of the active PI3K complex, conversion of PIP2 into PIP3, and activation of AKT signaling. Phospholipase C-gamma1 (PLCG1) can also be recruited directly, through EGFR phosphotyrosine residues that serve as PLCG1 docking sites, which leads to PLCG1 phosphorylation by EGFR and activation of DAG and IP3 signaling. EGFR signaling is downregulated by the action of ubiquitin ligase CBL. CBL binds directly to the phosphorylated EGFR dimer through the phosphotyrosine Y1045 in the C-tail of EGFR, and after CBL is phosphorylated by EGFR, it becomes active and ubiquitinates phosphorylated EGFR dimers, targeting them for degradation. For a recent review of EGFR signaling, please refer to Avraham and Yarden, 2011.

  EGFR 信号通路示意图

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  基因功能分类

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  ERBB2 signaling pathway	EGF, EGFR, AKT1, GAB1, HRAS, KRAS, NRAS, PIK3CA, PIK3R1, RPS27A, SHC1, SOS1, SRC, UBA52
  hsa04151 PI3K-Akt signaling pathway	AKT3, CDKN1A, CDKN1B, THEM4, CREB1, EGF, EGFR, AKT1, AKT2, FGFR1, PHLPP2, FOXO3, FGF22, GSK3B, NR4A1, HRAS, KRAS, MDM2, NRAS, PDPK1, PIK3CA, PIK3R1, MAPK1, MAPK3, MAP2K1, MAP2K2, PTEN, RAF1, RPS6KB2, SOS1, YWHAB
  intracellular signal transduction	AKT3, ADCY1, ADCY3, AKT1, AKT2, GSK3B, PDPK1, PLCG1, PRKAR1A, PRKAR2A, PRKAR2B, PRKCD, PRKCE, PRKCG, PAG1, RAF1, RPS6KB2, SHC1, SRC, CAMK4, ARHGEF7
  MAPK cascade	EGF, EGFR, FGFR1, FGF22, HRAS, KRAS, NRAS, MAPK1, MAPK3, MAP2K1, MAP2K2, RAF1, RPS27A, SHC1, SOS1, UBA52, YWHAB, CALM1
  negative regulation of epidermal growth factor receptor signaling pathway	SPRY1, SPRY2, AP2M1, AP2S1, CLTA, EGF, EGFR, EPS15, EPN1, SH3KBP1, EPS15L1, RPS27A, SH3GL2, UBA52, STAM, ARHGEF7, HGS, CDC42
  protein tyrosine kinase activity	CSK, EGF, EGFR, FGFR1, FGF22, MAP2K1, MAP2K2, SRC

   

   

  参考文献

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• Herbst RS. Review of epidermal growth factor receptor biology. Int J Radiat Oncol Biol Phys. 2004;59(2 Suppl):21-6
• Schlessinger J. Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell. 2002 Sep 20;110(6):669-72
• Carpenter G. Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways. J Cell Biol. 1999 Aug 23;146(4):697-702
• Wells A. EGF receptor. Int J Biochem Cell Biol. 1999 Jun;31(6):637-43
服务条款

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发货速度

现货：订单核实后5个工作日内发货；定制：15-20个工作日。

 

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