| Helioxanthin 8-1inhibitor of HBV and HIV virus |
Sample solution is provided at 25 µL, 10mM.
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- Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
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| Cas No. | 840529-13-7 | SDF | Download SDF |
| Chemical Name | 11-(benzo[d][1,3]dioxol-5-yl)-[1,3]dioxolo[4",5":3,4]benzo[1,2-g]phthalazine-7,10-diol | ||
| Canonical SMILES | OC1=NN=C(O)C2=C1C=C3C=CC(OCO4)=C4C3=C2C5=CC6=C(OCO6)C=C5 | ||
| Formula | C20H12N2O6 | M.Wt | 376.32 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
Helioxanthin 8-1, an analogue of helioxanthin (ACH126447), is an inhibitor of HBV and HIV virus with EC50 values of 0.03 μM and 2.7 μM, respectively [1].
Helioxanthin 8-1 is the cyclic hydrazide derivative of helioxanthin and has shown significant in vitro antivirus activity with EC50 values of 0.03 μM and 2.7 μM for HBV and HIV, respectively [1]. In the ds-tet5 cells, helioxanthin 8-1 can inhibit duck hepatitis B virus (DHBV) DNA synthesis with a mean IC50 value of 0.25±0.05 μM. Besides, in induced cells and non-induced ds-tet5 cells, helioxanthin 8-1 has cytotoxic effect with CC50 values of 18±2 μM and 45±3 μM, respectively, by using an MTT assay [2].
References:[1] Yeo H1, Li Y, Fu L, Zhu JL, Gullen EA, Dutschman GE, Lee Y, Chung R, Huang ES, Austin DJ, Cheng YC.Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46.[2] Ying C1, Tan S, Cheng YC. Helioxanthin analogue 8-1 inhibits duck hepatitis B virus replication in cell culture. Antivir Chem Chemother. 2010;21(2):97-103.
