| CCT007093PPM1D inhibitor |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
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- Purity = 99.83%
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Chemical structure
| Description | CCT007093 is a potent inhibitor of PPM1D (WIP1) with IC50 value of 8.4 μM. | |||||
| Targets | WIP1 | |||||
| IC50 | 8.4 μM | |||||
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| Cas No. | 176957-55-4 | SDF | Download SDF |
| Chemical Name | (2Z,5E)-2,5-bis(thiophen-2-ylmethylidene)cyclopentan-1-one | ||
| Canonical SMILES | C1CC(=CC2=CC=CS2)C(=O)C1=CC3=CC=CS3 | ||
| Formula | C15H12OS2 | M.Wt | 272.39 |
| Solubility | ≥3.4mg/mL in DMSO | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
CCT007093 is a small-molecule chemical inhibitor of PPM1D with IC50 value of 8.4μM [1].
CCT007093 is a thienylidene cyclopentanone and shows a potent inhibition of PPM1D in the in vitro assay when using the recombinant phospho-P38 as a substrate. In cellular assay, CCT007093 shows specificity for MCF-7 cells over HeLa cells. It reduces 40% viability of the cells after 2 days. It is found that the cell death induced by CCT007093 is dependent on P38 kinase activity. CCT007093 mimics the effect of PPM1D RNAi in activating P38 kinase. It induces P38 phosphorylation at 4 h post-exposure in MCF-7 cells and the loss of viability can be rescued by SB203580, the specific P38 inhibitor [1].
References:[1] Rayter S, Elliott R, Travers J, Rowlands MG, Richardson TB, Boxall K, Jones K, Linardopoulos S, Workman P, Aherne W, Lord CJ, Ashworth A. A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D. Oncogene. 2008 Feb 14;27(8):1036-44.
