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ApexBio/Dipraglurant/5mg/A3366

价格
¥51480.00
货号:A3366
浏览量:111
品牌:ApexBio
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DipraglurantmGluR5 antagonist

Catalog No.A3366
SizePriceStockQty
5mg
$498.00
In stock
10mg
$686.00
In stock
50mg
$2,574.00
In stock

Tel: +1-832-696-8203

Email: sales@apexbt.com

Worldwide Distributors

Sample solution is provided at 25 µL, 10mM.

Product Citations

1. Sengmany K, Hellyer SD, et al. "Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology." Neuropharmacology. 2019 May 1;149:83-96.PMID:30763654

Quality Control

Quality Control & MSDS

View current batch:
    Purity = 98.00%
  • COA (Certificate Of Analysis)
  • MSDS (Material Safety Data Sheet)
  • Datasheet

Chemical structure

Dipraglurant

Related Biological Data

Dipraglurant

Dipraglurant Dilution Calculator

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Dipraglurant Molarity Calculator

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Chemical Properties

Cas No. 872363-17-2SDF Download SDF
Synonyms ADX 48621;ADX48621;ADX-48621
Chemical Name 6-fluoro-2-(4-pyridin-2-ylbut-3-ynyl)imidazo[1,2-a]pyridine
Canonical SMILES C1=CC=NC(=C1)C#CCCC2=CN3C=C(C=CC3=N2)F
Formula C16H12FN3 M.Wt 265.29
Solubility Soluble in DMSO Storage Store at -20°C
Shipping ConditionEvaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

Dipraglurant (ADX 48621) is mGlu5 receptor negative allosteric modulator.

ApexBio的3X FLAG Peptide FLAG标签系统利用与目标蛋白质1融合的短而亲水的8个氨基酸的肽段。FLAG肽与抗体M1结合。结合是钙依赖性方式2还是非依赖性3仍存在争议。该系统的缺点是单克隆抗体纯化基质不如其他基质稳定。通常,可以用特异性单克隆抗体检测小标签。为了改善对FLAG标签的检测,已经开发了3x FLAG系统。这种三级FLAG表位是亲水的,长22个氨基酸,可以检测到高达10 fmol的表达融合蛋白。激烈热球菌的带有FLAG标签的麦芽糖糊精结合蛋白已被结晶4,其晶体质量与未标记蛋白的晶体质量非常相似。 最后,可以通过用肠激酶处理去除FLAG标签,肠激酶对肽序列5的5个C末端氨基酸具有特异性。