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PalifosfamideActive metabolite of ifosfamide (IFOS) |
Sample solution is provided at 25 µL, 10mM.
Quality Control & MSDS
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- Purity = 98.00%
- COA (Certificate Of Analysis)
- NMR (Nuclear Magnetic Resonance)
- MSDS (Material Safety Data Sheet)
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Chemical structure
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Cas No. | 31645-39-3 | SDF | Download SDF |
Synonyms | Isophosphoramide mustard;IPM;ZIO-201 | ||
Chemical Name | bis(2-chloroethylamino)phosphinic acid | ||
Canonical SMILES | C(CCl)NP(=O)(NCCCl)O | ||
Formula | C4H11Cl2N2O2P | M.Wt | 221.02 |
Solubility | ≥22.1 mg/mL in DMSO, <2.49 mg/ml="" in="" etoh,="" ≥19.4="" mg/ml="" in="" h2o="" with="" ultrasonic="" and="" warming="">2.49> | Storage | Store at -20°C |
Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. |
Palifosfamide is the active moiety of ifosfamide (IFA) [1].IFA is alkylating agents which are active against a variety of pediatric sarcomas such as rhabdomyosarcoma (RMS), Ewing’s sarcoma (ES), osteosarcoma (OS) and other undifferentiated soft tissue sarcomas [1].In human OS cell lines SaOS-2, OS229 and OS230, Palifosfamide lysine has broad activity with IC50 ranging from 2.25 to 6.75 μM. While OS222 had the IC50 of 31.5 μM [1].In CB17 female SCID mice, palifosfamide lysine (100 mg/kg) administered intravenously for three consecutive days, the mean weight loss was less than 15% and complete recovery to baseline within 4 weeks of treatment. While, doses higher than 100 mg/kg for three consecutive days lead to either greater than 20% loss of body weight or death. In NCr-nu/nu mice bearing established orthotopic mammary MX-1 tumor xenografts, palifosfamide suppressed MX-1 tumor growth by greater than 80% with 17% complete antitumor responses [2]. References:[1]. Hingorani P, Zhang W, Piperdi S, et al. Preclinical activity of palifosfamide lysine (ZIO-201) in pediatric sarcomas including oxazaphosphorine-resistant osteosarcoma. Cancer Chemother Pharmacol, 2009, 64(4): 733-740. [2]. Jones B, Komarnitsky P, Miller GT, et al. Anticancer activity of stabilized palifosfamide in vivo: schedule effects, oral bioavailability, and enhanced activity with docetaxel and doxorubicin. Anticancer Drugs, 2012, 23(2): 173-184.