| SR 0987agonist of the T cell-specific isoform of RORγ |
Sample solution is provided at 25 µL, 10mM.
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- Purity = 98.00%
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- MSDS (Material Safety Data Sheet)
Chemical structure
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| Cas No. | 303126-97-8 | SDF | Download SDF |
| Chemical Name | 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzamide | ||
| Canonical SMILES | ClC1=CC=CC=C1C(NC2=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C2)=O | ||
| Formula | C16H10ClF6NO2 | M.Wt | 397.7 |
| Solubility | ≤30mg/ml in ethanol;15mg/ml in DMSO;20mg/ml in dimethyl formamide | Storage | Store at -20°C |
| Physical Appearance | A crystalline solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
SR 0987 is an agonist of RORγt with EC50 value of ~800 nM for inducing reporter gene expression [1].
RORγt (retinoic acid receptor-related orphan receptor-γt), the T cell-specific isoform of RORγ, is the key lineage-defining transcription factor to initiate the differentiation program of TH17 and Tc17 cells, cells that have demonstrated anti-tumor efficacy [1].
SR 0987 is a RORγt agonist. In murine EL4 T lymphocytes, SR 0987 increased expression of IL17 while repressing the expression of the checkpoint receptor PD-1, suggesting that SR 0987 enhanced protective immunity by regulating expression of IL17 and PD-1 while maintaining the cytotoxic ability of these cells. In both the 5xRORE and IL17 promoter transfected cells, SR0987 concentration dependently induced reporter gene expression with an EC50 of ~800 nM. SR0987 also concentration dependently increased interaction of RORγt with the SRC1-3 NR box peptide [1].
Reference:[1]. Chang MR, Dharmarajan V, Doebelin C, et al. Synthetic RORγt Agonists Enhance Protective Immunity. ACS Chem Biol. 2016 Apr 15;11(4):1012-8.
