| all-trans Retinalconverted to retinoic acid in vivo |
Sample solution is provided at 25 µL, 10mM.
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- Purity = 98.17%
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| Cas No. | 116-31-4 | SDF | Download SDF |
| Synonyms | Retinaldehyde,Vitamin A aldehyde | ||
| Chemical Name | retinal | ||
| Canonical SMILES | CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C([H])=O)C(C)(C)CCC1 | ||
| Formula | C20H28O | M.Wt | 284.4 |
| Solubility | ≥57.4 mg/mL in DMSO, ≥56.6 mg/mL in EtOH, <1.45 mg/ml="" in="" h2o=""> | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
All-trans Retinal, also known as Vitamin A aldehyde or Retinaldehyde, is one of the many forms of vitamin A and also the oxidation product of all-trans retinol [1]. All-trans Retinal are associated with one of the two isoforms of cellular retinol-binding proteins (CRBP-I and CRBP-II) with Kd values of 50 and 90 nM, respectively [1].
CRBP-I and CRBP-II were the first intracellular retinoid-binding proteins. Both proteins display a similar binding affinity towards retinal. They play important roles in retinoid biology and regulation of the metabolism of retinol and retinal. CRBP-I is used to regulate vitamin A storage and synthesis of retinoic acid. And CRBP-II has a role in the initial processing of retinol from food [1].
All-trans Retinal is one form of vitamin A. All-trans Retinal, the initial substrate of retinoid cycle, is a chemically reactive aldehyde that can form toxic conjugates with proteins and lipids, leading to degeneration of the retina [2].
References:[1]. Noy N. Retinoid-binding proteins: mediators of retinoid action. Biochem J. 2000 Jun 15;348 Pt 3:481-95.[2]. Kiser PD, Golczak M, Maeda A, et al. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta. 2012 Jan;1821(1):137-51.
