| A23187, free acidCa2+ ionophore |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
Nature.2018 Nov;563(7731):407-411.Nature.2018 Jun 13.Nature.2018 Jun 27.Nature.2018 Mar 29;555(7698):673-677.Nature.2017 Sep 7;549(7670):96-100.Nature.2016 Apr 21;532(7599):398-401.
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- Purity = 98.00%
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Chemical structure
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| Cas No. | 52665-69-7 | SDF | Download SDF |
| Chemical Name | 5-(methylamino)-2-(((2S,3S,6S,8R,9S,11S)-3,9,11-trimethyl-8-((S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl)-1,7-dioxaspiro[5.5]undecan-2-yl)methyl)benzo[d]oxazole-4-carboxylic acid | ||
| Canonical SMILES | O=C(C1=CC=CN1)[C@@H](C)[C@@H]2O[C@@]3([C@@H](C)C[C@@H]2C)O[C@@H](CC4=NC5=C(C(O)=O)C(NC)=CC=C5O4)[C@@H](C)CC3 | ||
| Formula | C29H37N3O6 | M.Wt | 523.63 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| Physical Appearance | A crystalline solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
A23187, free acid is a Ca2+ ionophore [1].
Ca2+ ionophore acts as a Ca2+ ionophore, allowing Ca2+ to cross cell membranes.
A23187, free acid is a Ca2+ ionophore. In rat Kupffer cells, A23187 induced hydrolysis of phosphoinositides to inositol phosphates and released inositol phosphates from the cells in a concentration- and time-dependent way [1]. In HL-60 cells, A23187 increased intracellular Ca2+ levels. Also, A23187 generated reactive oxygen species (ROS) both in intracellular and extracellular and induced apoptotic cell death, which was dependent on mitochondrial permeability transition [2]. In ileal muscle, A23187 (10-5 M) induced initial contraction and small rhythmic contractions with decrease in phosphocreatinine (PCr), ATP and glycogen contents under hypoxic conditions. However, A23187 (10-5 M) induced initial contraction and successive rhythmic contractions with a significant decrease in the ATP and glycogen contents in glucose-free medium [3]. In rat C6 glioma cells that was resistant to ZnCl2 (250 μM), A23187 (100 nM) and Zn2+ (150 μM) significantly induced apoptosis. Also, A23187 (1.9 nM) significantly increased the intracellular mobile Zn2+ content. These results suggested that the apoptosis induced by Zn2+ and A23187 was the result of increased Zn2+ influx induced by A23187 [4].
References:[1]. Gandhi CR, Harvey SA, Cevallos M, et al. A23187 causes release of inositol phosphates from cultured rat Kupffer cells. Eur J Pharmacol, 2001, 415(1): 13-18.[2]. Kajitani N, Kobuchi H, Fujita H, et al. Mechanism of A23187-induced apoptosis in HL-60 cells: dependency on mitochondrial permeability transition but not on NADPH oxidase. Biosci Biotechnol Biochem, 2007, 71(11): 2701-2711. [3]. Nasu T, Nishikawa M. Metabolic dependency of ionophore A23187-induced contraction of ileal longitudinal smooth muscle. J Auton Pharmacol, 2000, 20(2): 99-109.[4]. Jansen S, Arning J, Beyersmann D. Effects of the Ca ionophore a23187 on zinc-induced apoptosis in C6 glioma cells. Biol Trace Elem Res, 2003, 96(1-3): 133-142.
