| 5,8,11-Eicosatriynoic Acidnonselective inhibitor of lipoxygenases (12-LO) |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
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- Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
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| Cas No. | 13488-22-7 | SDF | Download SDF |
| Synonyms | 5,8,11-ETI | ||
| Chemical Name | 5,8,11-eicosatriynoic acid | ||
| Canonical SMILES | CCCCCCCCCCCCCCCCCCCC(=O)O | ||
| Formula | C20H28O2 | M.Wt | 300.4 |
| Solubility | ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide | Storage | Store at -20°C |
| Physical Appearance | A crystalline solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
5,8,11-Eicosatriynoic Acid is a selective inhibitor of lipoxygenases with ID50 values of 24 μM and 340 μM for n-8 lipoxygenase and fatty acid cycle-oxygenase , respectively[1][2].
Fatty acid cycle-oxygenase and n-8 lipoxygenase catalyze the initial reactions which lead to the formation of three major arachidonic acid metabolites in human platelets. In several tissues, these two enzymes act concomitantly on arachidonic acid [1].
5,8,11-Eicosatriynoic Acid (5,8,11-ET) is a selective inhibitor of lipoxygenases with ID50 values of 24 μM and 340 μM for n-8 lipoxygenase and fatty acid cycle-oxygenase, respectively. 5,8,11-Eicosatriynoic acid was useful for studies on physiological and pathophysiological roles of 12 L-hydroxy-5,8,10,14-eicosatetraenoic acid formation in various tissues [1]. In mouse mastocytoma cells, 5,8,11-Eicosatriynoic Acid inhibited A23187 and L-cysteine induced leukotriene C (LTC4) biosynthesis with ID50 value of 5 μM [2].
References:[1]. Hammarstrm S. Selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. Biochim Biophys Acta. 1977 Jun 22;487(3):517-9. [2]. Orning L, Hammarstrm S. Inhibition of leukotriene C and leukotriene D biosynthesis. J Biol Chem. 1980 Sep 10;255(17):8023-6.
