| Pyrrolidino PAF C-16potent mediator of PAF-like activitie |
Sample solution is provided at 25 µL, 10mM.
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- Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
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| Cas No. | 91021-63-5 | SDF | Download SDF |
| Chemical Name | 1-O-hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphoryl-N-methyl-pyrrolidinium ethanol | ||
| Canonical SMILES | CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP(OCC[N+]1(C)CCCC1)([O-])=O | ||
| Formula | C28H56NO7P | M.Wt | 549.7 |
| Solubility | ≤25mg/ml in PBS | Storage | Store at -20°C |
| Physical Appearance | A lyophilized powder | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
Pyrrolidino PAF C-16 is a synthetic analog of PAF C-16 with hypotensive action [1][2].
Plateletactivatingfactor(PAF;C16), aphospholipidmediator ofinflammation,issecretedbyseveralcelltypesincludingarterialendothelialcells, andcanactivatepolymorphonuclearleucocytesandmonocytesviaspecificcellsurface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages. PAF have potent hypotensive activity. C16-PAF was about three times more potent than C18-PAF in the activity of releasing serotonin [1][2].
Pyrrolidino PAF C-16, a synthetic analog of PAF C-16, is a potent mediator of PAF-like activities, including hypotension and platelet aggregation [1][2].
In male Wistar rats, Pyrrolidino PAF C-16 dose-dependently decreased blood pressure and the duration of the hypotension was also dose-dependent. Pyrrolidino PAF C-16 was 3-10 times more potent than natural PAF in the hypotensive activity [1][2].
References:[1]. Shigenobu K, Masuda Y, Tanaka Y, et al. Platelet activating factor analogues: lack of correlation between their activities to produce hypotension and endothelium-mediated vasodilation. J Pharmacobiodyn. 1985 Feb;8(2):128-33.[2]. Kasuya Y, Masuda Y, Shigenobu K. Hypotensive actions of some analogues of platelet-activating factor (PAF) with higher potencies than natural PAF. Can J Physiol Pharmacol. 1984 Apr;62(4):457-9.
