| (±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolanePAF receptor antagonist |
Sample solution is provided at 25 µL, 10mM.
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(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane Dilution Calculator
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| Cas No. | 116673-45-1 | SDF | Download SDF |
| Synonyms | trans-BTP Dioxolane | ||
| Chemical Name | trans-(±)-2,4-bis(3,4,5-trimethoxyphenyl)-1,3-dioxolane | ||
| Canonical SMILES | COC1=CC([C@H]2O[C@H](C3=CC(OC)=C(OC)C(OC)=C3)OC2)=CC(OC)=C1OC | ||
| Formula | C21H26O8 | M.Wt | 406.4 |
| Solubility | ≤35mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide | Storage | Store at -20°C |
| Physical Appearance | A crystalline solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane, also known as trans-BTP Dioxolane, is a PAF receptor antagonist [1].
Plateletactivatingfactor(PAF), aphospholipidmediator ofinflammation,issecretedbyseveralcelltypesincludingarterialendothelialcells, andcanactivatepolymorphonuclearleucocytesandmonocytesviaspecificcellsurface receptors. PAF also stimulates the production of active oxygen species by human monocyte - derived macrophages. PAF play important roles in a variety of pathophysiological states including acute allergy, inflammation, asthma, gastrointestinal ulceration, and toxic shock [1].
(±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane is a PAF receptor antagonist. In the rabbit washed platelet assay, (±)trans-2,5-bis-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane showedgood competitive PAF antagonism with Ki value of 0.3 μM, whereas the cis-isomer was much less active.
Reference:[1]. Corey, E.J.,Chen, C.P., and Parry, M.J. Dual binding modes to the receptor for platelet activating factor (PAF) of anti-PAF trans-2,5-diarylfurans. Tetrahedron Letters 29, 2899-2902 (1988).
