ApexBio蚂蚁淘在线

Size	Price	Stock	Qty
1mg	$461.00	In stock

Publications citing ApexBio Products

Nature.2017 Jan 19;541(7637):417-420.

Nature.2018 Nov;563(7731):407-411.

Nature.2018 Jun 13.

Nature.2018 Jun 27.

Nature.2018 Mar 29;555(7698):673-677.

Nature.2017 Sep 7;549(7670):96-100.

Nature.2016 Apr 21;532(7599):398-401.

Science.2016 Aug 5;353(6299)594-8

Nat Nanotechnol.2017 Dec;12(12):1190-1198.

Nature Biotechnology.2017 Jun;35(6):569-576

Nat Med.2018 Sep 17.

Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.

Cell.Available online 25 October 2018.

Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.

Cell.2018 Jun 28;174(1):172-186.e21.

Cell.2018 Feb 22;172(5):1007-1021.e17.

Cell.2017 Nov 30;171(6):1284-1300.e21.

Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.

Cell.2017 Jul 13;170(2):312-323

Nat Med.2018 Jan 29.

Nat Med.2017 Nov;23(11):1342-1351.

Cell.2017 Apr 6;169(2):286-300.

Cell.2015 Aug 27;162(5):987-1002.

Cell.2015 Feb 12;160(4):729-44.

Nature Medicine.2017 Apr;23(4):493-500.

Cancer Cell.2018 May 14;33(5):905-921.e5.

Cancer Cell.2018 Apr 9;33(4):752-769.e8.

Cancer Cell.2018 Mar 12;33(3):401-416.e8.

Cancer Cell.2017 Aug 14;32(2):253-267.e5.

Nat Methods.2018 Jul;15(7):523-526.

Cell Stem Cell.2018 May 3;22(5):769-778.e4.

Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.

Quality Control

Quality Control & MSDS

View current batch:

Purity = 98.00%

COA (Certificate Of Analysis)
MSDS (Material Safety Data Sheet)
Datasheet

Chemical structure

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Chemical Properties

Cas No.	211364-78-2	SDF	Download SDF
Chemical Name	(3S,4Z,6S,7Z,9S,10Z,12S,13Z,15S,16Z,18S,19Z,21S,22Z,24S)-12-((1H-indol-3-yl)methyl)-18-(carboxymethyl)-24-((1Z,3S,4Z,6S,7Z,9S,10Z,12R,13Z,15S)-15-((S)-2-carboxypyrrolidine-1-carbonyl)-1,4,7,10,13-pentahydroxy-6-(2-hydroxy-2-iminoethyl)-12-(mercaptomethyl)
Canonical SMILES	CC(C[C@@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@]1([H])CCCN1C([C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@]2([H])CCCN2)([H])CC3=CN=CN3)([H])CS)([H])C(C)C)=O)([H])CCCNC(N)=N)([H])CC(O)=O)([H])CC
Formula	C₁₀₁H₁₅₇N₂₇O₂₉S₃	M.Wt	2309.69
Solubility	Soluble to 1 mg/ml in H2O	Storage	Desiccate at -20°C
Physical Appearance	White lyophilised solid	Shipping Condition	Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

Background

Antagonist of 14.3.3 proteins (K_D ≈80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. Blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S. Induces apoptosis.

ApexBio/R18/1mg/A4446