| Methyl α-Linolenyl Fluorophosphonateinhibitor of phospholipases, FAAH |
Sample solution is provided at 25 µL, 10mM.
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Methyl α-Linolenyl Fluorophosphonate Dilution Calculator
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Methyl α-Linolenyl Fluorophosphonate Molarity Calculator
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| Cas No. | SDF | Download SDF | |
| Synonyms | MLnFP | ||
| Chemical Name | 9Z,12Z,15Z-octadecatrienyl-phosphonofluoridic acid, methyl ester | ||
| Canonical SMILES | CC/C=CC/C=CC/C=CCCCCCCCCP(=O)(F)OC | ||
| Formula | C19H34FO2P | M.Wt | 344.4 |
| Solubility | ≤5mg/ml in ethanol;5mg/ml in DMSO;5mg/ml in dimethyl formamide | Storage | Store at -20°C |
| Physical Appearance | A solution in methyl acetate | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
Methyl α-Linolenyl Fluorophosphonate is an inhibitor of phospholipases.
Methyl α-linolenyl fluorophosphonate (MLnFP), an analog of methyl arachidonyl fluorophosphonate (MAFP), has not been completely investigated for its pharmacological activity.
In vitro: Methyl arachidonyl fluorophosphonate (MAFP) was reported to be a selective, active-site directed, irreversible inhibitor of cytosolic phospholipase A2 (cPLA2). MAFP could also potently inhibit the Ca2+-independent cytosolic phospholipase A2 (iPLA2) in a concentration-dependent manner. Such inhibition was not reversed upon extensive dilution of the enzyme into the assay mixture. Preincubation of iPLA2 with MAFP led to a linear and time-dependent inactivation of enzyme activity, and the enzyme was protected from inactivation by the reversible inhibitor. The ability of MAFP to inhibit the iPLA 2 indicated that this enzyme proceeded via an acyl-enzyme intermediate. Further testing showed that MAFP could not inhibit the CoA-dependent acyltransferase, arachidonoyI-CoA synthetase, or CoA-independent transacylase activities. Therefore, MAFP was not a general inhibitor for enzymes acting on arachidonoyi substrates [1].
In vivo: Up to now, there is no animal in vivo data reported.
Clinical trial: So far, no clinical study has been conducted.
Reference:[1] Lio, Y.C.,Reynolds, L.J.,Balsinde, J., et al. Irreversible inhibition of Ca2+-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochimica et Biophysica Acta 1302, 55-60 (1996).
