- Atazanavir
- Tipranavir
- Narlaprevir
- Ritonavir
- Danoprevir (RG7227)
- Saquinavir mesylate
| Atazanavir sulfate (BMS-232632-05)Protease inhibitor |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
Nature.2018 Nov;563(7731):407-411.Nature.2018 Jun 13.Nature.2018 Jun 27.Nature.2018 Mar 29;555(7698):673-677.Nature.2017 Sep 7;549(7670):96-100.Nature.2016 Apr 21;532(7599):398-401.
Science.2016 Aug 5;353(6299)594-8Nat Nanotechnol.2017 Dec;12(12):1190-1198.Nature Biotechnology.2017 Jun;35(6):569-576Nat Med.2018 Sep 17.Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.Cell.Available online 25 October 2018.Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.Cell.2018 Jun 28;174(1):172-186.e21.Cell.2018 Feb 22;172(5):1007-1021.e17.Cell.2017 Nov 30;171(6):1284-1300.e21.Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.Cell.2017 Jul 13;170(2):312-323Nat Med.2018 Jan 29.Nat Med.2017 Nov;23(11):1342-1351.Cell.2017 Apr 6;169(2):286-300.Cell.2015 Aug 27;162(5):987-1002.Cell.2015 Feb 12;160(4):729-44.Nature Medicine.2017 Apr;23(4):493-500.Cancer Cell.2018 May 14;33(5):905-921.e5.Cancer Cell.2018 Apr 9;33(4):752-769.e8.Cancer Cell.2018 Mar 12;33(3):401-416.e8.Cancer Cell.2017 Aug 14;32(2):253-267.e5.Nat Methods.2018 Jul;15(7):523-526.Cell Stem Cell.2018 May 3;22(5):769-778.e4.Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.Quality Control & MSDS
- View current batch:
- Purity = 99.68%
- COA (Certificate Of Analysis)
- HPLC (Retest)
- NMR (Nuclear Magnetic Resonance)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
Related Biological Data
Related Biological Data
Atazanavir sulfate (BMS-232632-05) Dilution Calculator
calculate
Atazanavir sulfate (BMS-232632-05) Molarity Calculator
calculate
| Cas No. | 229975-97-7 | SDF | Download SDF |
| Synonyms | Atazanavir Bisulfate SaltSee A790051,BMS232632-05 | ||
| Chemical Name | methyl N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-4-phenylbutyl]-2-[(4-pyridin-2-ylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate;sulfuric acid | ||
| Canonical SMILES | CC(C)(C)C(C(=O)NC(CC1=CC=CC=C1)C(CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)C(C(C)(C)C)NC(=O)OC)O)NC(=O)OC.OS(=O)(=O)O | ||
| Formula | C38H52N6O7.H2SO4 | M.Wt | 802.9 |
| Solubility | ≥28.7 mg/mL in DMSO with gentle warming, ≥4.05 mg/mL in EtOH with ultrasonic and warming, <2.43 mg/ml="" in="" h2o=""> | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
Atazanavir sulfate (BMS-232632-05) is the sulfate salt form of atazanavir, a potent protease inhibitor (IP) for the treatment of human immunodeficiency virus 1 (HIV-1) infection, which prevents the formation of mature HIV virions through the selective inhibition of the virus-specific processing of viral gag and gag-pol polyproteins in infected cells. Although it shows strong anti-HIV-1 activity with MIC50 ranging from 2 to 5 nM, atazanavir has lower antiviral activity against HIV-2 isolates. Atazanavir, which is metabolized by the hepatic cytochrome P450 (CYP) system resulting in two main inactive metabolites, is also an inhibitor of CYP3A4 isoenzyme and P-glycoprotein ATP-dependent efflux pump.
Reference
Robin Wood. Atazanavir: its role in HIV treatment. Expert Rev Snti Infect Ther 2008; 6(6): 785-796
