- Pitavastatin Calcium
- Pravastatin sodium
- Simvastatin (Zocor)
- Fluvastatin
- Pitavastatin
- Atorvastatin Calcium
| Fluvastatin SodiumHMG-CoA reductase inhibitor |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
Nature.2018 Nov;563(7731):407-411.Nature.2018 Jun 13.Nature.2018 Jun 27.Nature.2018 Mar 29;555(7698):673-677.Nature.2017 Sep 7;549(7670):96-100.Nature.2016 Apr 21;532(7599):398-401.
Science.2016 Aug 5;353(6299)594-8Nat Nanotechnol.2017 Dec;12(12):1190-1198.Nature Biotechnology.2017 Jun;35(6):569-576Nat Med.2018 Sep 17.Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.Cell.Available online 25 October 2018.Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.Cell.2018 Jun 28;174(1):172-186.e21.Cell.2018 Feb 22;172(5):1007-1021.e17.Cell.2017 Nov 30;171(6):1284-1300.e21.Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.Cell.2017 Jul 13;170(2):312-323Nat Med.2018 Jan 29.Nat Med.2017 Nov;23(11):1342-1351.Cell.2017 Apr 6;169(2):286-300.Cell.2015 Aug 27;162(5):987-1002.Cell.2015 Feb 12;160(4):729-44.Nature Medicine.2017 Apr;23(4):493-500.Cancer Cell.2018 May 14;33(5):905-921.e5.Cancer Cell.2018 Apr 9;33(4):752-769.e8.Cancer Cell.2018 Mar 12;33(3):401-416.e8.Cancer Cell.2017 Aug 14;32(2):253-267.e5.Nat Methods.2018 Jul;15(7):523-526.Cell Stem Cell.2018 May 3;22(5):769-778.e4.Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.Quality Control & MSDS
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- Purity = 98.84%
- COA (Certificate Of Analysis)
- HPLC (Retest)
- NMR (Nuclear Magnetic Resonance)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
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| Cas No. | 93957-55-2 | SDF | Download SDF |
| Synonyms | N/A | ||
| Chemical Name | sodium;7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate | ||
| Canonical SMILES | CC(C)N1C2=CC=CC=C2C(=C1C=CC(CC(CC(=O)[O-])O)O)C3=CC=C(C=C3)F.[Na+] | ||
| Formula | C24H25FNNaO4 | M.Wt | 433.45 |
| Solubility | ≥18.15 mg/mL in DMSO, ≥16.83 mg/mL in EtOH, ≥8.22 mg/mL in H2O | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
Fluvastatin sodium is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase [1].
Fluvastatin is a drug used to treat patients with hypercholesterolaemia. It lowers serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) as well as the serum apolipoprotein B. It also increases high density lipoprotein cholesterol (HDL-C) levels and apolipoprotein A-I levels. In addition to these, fluvastatin has antiatherogenic, antithrombotic and antioxidant effects. In U937 human monocyte cells, fluvastatin reduces the expression of adhesion molecules thus reducing the interaction between monocytes and endothelial cells. Fluvastatin dose-dependently reduces the platelet aggregation in vitro. The administration of fluvastatin at dose of 40 mg/day to patients reduces platelet aggregation by 10 to 15% after 4 to 24 weeks. In patients with hypercholesterolaemia, fluvastatin 40 mg/day for 8 weeks can reduce copper-induced diene production in LDL-C isolated from these patients. It is also reported that, fluvastatin can inhibit the production of NO and decreases inflammatory angiogenesis induced by the sponge matrix [1, 2].
References:[1] Langtry HD, Markham A. Fluvastatin. A Review of its Use in Lipid Disorders. Drugs. 1999 Apr;57(4):583-606.[2] Fernanda A. Araujo, Monaliza A. Rocha, Luciano S. A. Capettini, Paula P. Campos, Monica A. N. D. Ferreira, Virginia S. Lemos1and Silvia P. Andrade. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012,121:422-430.
