- Adrenomedullin (1-12), human
- Myelopeptide-2 (MP-2)
- Epidermal Growth Factor Receptor Peptide (985-996)
- GTP-Binding Protein Fragment, G alpha
- Laminin (925-933)
| Cytochrome c - pigeon (88-104)Triggers T Cell response |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
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- Purity = 98.58%
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Chemical structure
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| Cas No. | 86579-06-8 | SDF | Download SDF |
| Synonyms | H2N-Lys-Ala-Glu-Arg-Ala-Asp-Leu-Ile-Ala-Tyr-Leu-Lys-Gln-Ala-Thr-Ala-Lys-OH | ||
| Chemical Name | N/A | ||
| Canonical SMILES | CCC(C)C(C(=O)NC(C)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)N)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CCCCN)N | ||
| Formula | C84H144N24O25 | M.Wt | 1890.19 |
| Solubility | ≥189mg/mL in DMSO | Storage | Store at -20°C |
| Physical Appearance | A solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
H-Lys-Ala-Glu-Arg-Ala-Asp-Leu-Ile-Ala-Tyr-Leu-Lys-Gln-Ala-Thr-Ala-Lys-OH
The I-Ek-restricted T cell response to Cytochrome c - pigeon (pcyt c) is specific for a peptide within the COOH-terminal sequence 88-1041.
The minimal length of the pcyt c peptide required for T cell stimulation is the COOH-terminal sequence containing residues 95-104. However, the addition of residues to the NH2 terminus of residue 95 increases the antigenic potency of the peptide; the maximal response is induced by pcyt c 88-1042.
The substitution of any residue between 95 and 104 of the cytochrome c peptide changed the antigenic potency of the peptide for at least one of the hybridomas3.
Figure1. Structure of Cytochrome c
Figure2. Formula of Cytochrome c - pigeon (88-104)
C84H144N24O25
Ref:
1. Schwartz, R. H. 1985. T lymphocyte recognition of antigen in association with gene products of the MHC. Annu. Rev. Immunol. 3:237.
2. Bhayani, H., F. R. Carbone, and Y. Paterson. 1988. The activation of pigeon cytochrome c-specific T cell hybridomas by antigenic peptides is influenced by non-native sequences at the amino terminus of the determinant. J. Immunol. 141:377.
3. Bhayani, H., Y. Paterson. 1989. Analysis of peptide binding patterns in different major histocompatibility complex/t cell receptor complexes using pigeon cytochrome c-specific t cell hybridomas.
