| MoxonidineI1R/α2AR agonist |
Sample solution is provided at 25 µL, 10mM.
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| Cas No. | 75438-57-2 | SDF | Download SDF |
| Synonyms | N/A | ||
| Chemical Name | 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine | ||
| Canonical SMILES | CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC | ||
| Formula | C9H12ClN5O | M.Wt | 241.68 |
| Solubility | ≥11.3 mg/mL in DMSO, ≥4.74 mg/mL in EtOH with ultrasonic, <2.25 mg/ml="" in="" h2o=""> | Storage | Store at -20°C |
| Physical Appearance | A solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
Moxonidine is an agonist of I1-imidazoline receptor with EC50 value of 1.3µM [1].
Moxonidine can bind to both I1-imidazoline receptor (I1R) and α2-adrenergic receptor (α2AR). The selectivity of moxonidine for I1R is 33-fold over α2AR. Moxonidine plays its antihypertensive role in the central nervous system. It has a central site of action. It is shown no effect in pithed rats and in cats following spinal cord transaction. Moxonidine also reduces sympathetic outflow and lowers peripheral vascular resistence [1, 2].
Besides the antihypertensive efficacy, Moxonidine is reported to have effects on gastric secretion and gastric mucosal injury in rats. It significantly reduces basal gastric acid secretion when given doses of 0.1 (63% inhibition) and 1.0 (65% inhibition) mg/kg. Even 0.01mg/kg moxonidine can reduce the gastric mucosal injury induced by ethanol [3].
References:[1] George OK, Gonzalez RR Jr, Edwards LP. Moxonidine, an antihypertensive agent, is permissive to alpha1-adrenergic receptor pathway in the rat-tail artery. J Cardiovasc Pharmacol. 2004 Feb;43(2):306-11.[2] Morris ST, Reid JL. Moxonidine: a review. J Hum Hypertens. 1997 Oct;11(10):629-35.[3] Glavin GB, Smyth DD. Effects of the selective I1 imidazoline receptor agonist, moxonidine, on gastric secretion and gastric mucosal injury in rats. Br J Pharmacol. 1995 Feb;114(4):751-4.
