- Enzastaurin (LY317615)
- Staurosporine
| (-)-epicatechininducer of pancreatic β-cell regeneration |
Sample solution is provided at 25 µL, 10mM.
Nature.2017 Jan 19;541(7637):417-420.
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- Purity = 98.94%
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| Cas No. | 490-46-0 | SDF | Download SDF |
| Chemical Name | (2R,3R)-2-(3,4-dihydroxyphenyl)chroman-3,5,7-triol | ||
| Canonical SMILES | O[C@@H]1CC2=C(C=C(O)C=C2O)O[C@@H]1C3=CC=C(O)C(O)=C3 | ||
| Formula | C15H14O6 | M.Wt | 290.27 |
| Solubility | ≥14.5mg/mL in DMSO | Storage | Store at -20°C |
| Physical Appearance | A solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
(-)-epicatechin is a flavonoid that increases NO levels and an inducer of pancreatic β-cell regeneration [1] [2].
β cells are a subset of cells in the pancreatic islets and play an important role in regulating glucose homeostasis through the production of insulin.
(-)-epicatechin is an inducer of pancreatic β-cell regeneration. In murine macrophages, (-)-epicatechin induced nitrite accumulation induced by interferon-γ/lipopolysaccharide with IC50 value of 0.5 mM. Also, (-)-epicatechin inhibited nitration of free tyrosine induced by 0.1 and 1 mM peroxynitrite with IC50 values of 6.6 and 28.0 µM, respectively. In HL-60 cells, (-)-epicatechin inhibited nitration of protein-bound tyrosine induced by phorbol 12-myristate 13-acetate with IC50 value of 10-100 µM [2]. In human endothelial cells (HUVEC), (-)-epicatechin (0.3-10 µM) increased NO levels, suggesting its vasodilatory properties [3].
In alloxan diabetic rats, (-)-epicatechin (30 mg/kg) lowered blood sugar and restored the amount of beta-cells against alloxan-induced necrosis of the beta-cell population in the pancreatic islets. In rats, (-)-epicatechin was non-toxic up to 1 g/kg [1]. In rats, oral administration of (-)-epicatechin metabolized to 3’-O-methyl-(-)-epicatechin and 4’-O-methyl-(-)-epicatechin [4].
References:[1]. Chakravarthy BK, Gupta S, Gambhir SS, et al. Pancreatic beta-cell regeneration in rats by (-)-epicatechin. Lancet, 1981, 2(8249): 759-760.[2]. Wippel R, Rehn M, Gorren AC, et al. Interference of the polyphenol epicatechin with the biological chemistry of nitric oxide- and peroxynitrite-mediated reactions. Biochem Pharmacol, 2004, 67(7): 1285-1295.[3]. Brossette T, Hundsdörfer C, Kröncke KD, et al. Direct evidence that (-)-epicatechin increases nitric oxide levels in human endothelial cells. Eur J Nutr, 2011, 50(7): 595-599.[4]. Okushio K, Suzuki M, Matsumoto N, et al. Identification of (-)-epicatechin metabolites and their metabolic fate in the rat. Drug Metab Dispos, 1999, 27(2): 309-316.
