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Description
Asiaticoside is a triterpene found in Centella that exhibits anti-inflammatory, neuroprotective, cognition enhancing, antipyretic, antioxidative, pro-angiogenic, anticancer chemotherapeutic, and chemopreventive activities. Asiaticoside inhibits melanogenesis by decreasing DNA binding by MITF; as a result, it is occasionally used in skin whitening treatments. Asiaticoside induces apoptosis, increases activation of caspase 3, decreases release of TNF-α and IL-1β, and suppresses tumor development and size in animal models of breast cancer. In animal models of cerebral ischemia/reperfusion, asiaticoside improves memory and learning deficits and decreases levels of IL-6, TNF-α, and IL-1β. Additionally, asiaticoside decreases LPS-induced inflammation and fever, suppresses activity of myeloperoxidase, and increases activity of heme oxygenase 1 (HO-1) in vivo. This compound also supports wound healing activity, increasing cell migration, attachment, and growth in vitro.
Product Info
16830-15-2 |
≥90% |
C48H78O19 |
959.12 |
(2α,3β,4α)-2,3,23-Trihydroxyurs-12-en-28-oic acid O-6-deoxy-a-L-mannopyranosyl-(1->4)-O-β-D-glucopyranosyl-(1->6)-O-β-D-glucopyranosyl ester |
[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl]10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate |
230-233°C |
Soluble in propylene glycol or ethanol. |
White Crystal Powder |
Shipping and Storage
4°C |
Ambient |
Downloads
A7333 MSDS PDF |
A7333 Info Sheet PDF |
References
Kwon KJ, Bae S, Kim K, et al. Asiaticoside, a component of Centella asiatica, inhibits melanogenesis in B16F10 mouse melanoma. Mol Med Rep. 2014 Jul;10(1):503-7. PMID: 24756377.
Chen S, Yin ZJ, Jiang C, et al. Asiaticoside attenuates memory impairment induced by transient cerebral ischemia-reperfusion in mice through anti-inflammatory mechanism. Pharmacol Biochem Behav. 2014 Jul;122:7-15. PMID: 24631487.
Al-Saeedi FJ. Study of the cytotoxicity of asiaticoside on rats and tumour cells. BMC Cancer. 2014 Mar 25;14:220. PMID: 24667059.
Wan J, Gong X, Jiang R, et al. Antipyretic and anti-inflammatory effects of asiaticoside in lipopolysaccharide-treated rat through up-regulation of heme oxygenase-1. Phytother Res. 2013 Aug;27(8):1136-42. PMID: 22972613.
Lee JH, Kim HL, Lee MH, et al. Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model. Phytomedicine. 2012 Oct 15;19(13):1223-7. PMID: 22939261.
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