Immunohistochemistry ServicesWork with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies. TCR Screening ServicesTest your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their \"Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use\". Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues. Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development. Worldwide Distributors List - To find your local distributor if you\'re not within the United States. order histories, retained contact details for faster checkout, review submissions, and special promotions. order histories, retained contact details for faster checkout, review submissions, and special promotions. Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) is a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. LRP6 functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade LRP6 plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. LRP6 undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined. LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy. Liu CC, Prior J, Piwnica-Worms D, Bu G. Proceedings of the National Academy of Sciences of the United States of America. 2010 107:5136-41. PubMed:20194742 PMC:PMC2841938 Related Antibodies: LS-C100405. Systems Genetics Analysis of a Recombinant Inbred Mouse Cell Culture Panel Reveals Wnt Pathway Member Lrp6 as a Regulator of Adult Hippocampal Precursor Cell Proliferation. Kannan S, Nicola Z, Overall RW, Ichwan M, Ram rez-Rodr guez G, N Grzyb A, Patone G, Saar K, H bner N, Kempermann G. Stem cells (Dayton, Ohio). 2016 March;34:674-84. (Human)Full Text Article PubMed:26840599 Price: 20µl$270.00; 50µl$295.00; 100µl$370.00; 200µl$485.00 Price: 20µl1.4mg/ml$260.00; 60µl1.4mg/ml$295.00; 120µl1.4mg/ml$370.00; 200µl1.4mg/ml$495.00 Price: 20µl$270.00; 50µl$295.00; 100µl$370.00; 200µl$485.00 Price: 60µl1mg/ml$295.00; 120µl1mg/ml$370.00; 200µl1mg/ml$495.00 Price: 20µl$270.00; 50µl$295.00; 100µl$370.00; 200µl$485.00 Price: 100µl0.5mg/ml$320.00; 200µl0.5mg/ml$385.00; 500µl0.5mg/ml$560.00; 1ml0.5mg/ml$665.00 Price: 200µl0.1mg/ml$560.00; 500µl0.1mg/ml$1,060.00; 1ml0.1mg/ml$1,315.00 If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development. PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).
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